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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109661
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|a eng
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| 100 |
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|a Al-Obeidi, Arshed F
|e verfasserin
|4 aut
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| 245 |
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|a Immunopathogenesis of Behçet's disease
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|c 2023
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 26.07.2023
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|a Date Revised 24.09.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 Elsevier Inc. All rights reserved.
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|a Behçet's disease (BD) is a multi-system inflammatory disorder with vasculitic features. It does not suit any of the current pathogenesis-driven disease classifications well, a unifying concept of its pathogenesis is not unanimously conceivable at present, and its etiology is obscure. Still, evidence from immunogenetic and other studies supports the notion of a complex-polygenic disease with robust innate effector responses, reconstitution of regulatory T cells upon successful treatment, and first clues to the role of an, as of yet, underexplored adaptive immune system and its antigen recognition receptors. Without an attempt to be comprehensive, this review aims to collect and organize impactful parts of this evidence in a way that allows the reader to appreciate the work done and define the efforts needed now. The focus is on literature and notions that drove the field into new directions, whether recent or more remote
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|a Review
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|a Research Support, N.I.H., Extramural
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|a Antigen-recognition
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|a Behcet
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|a CD8 T cells
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|a ERAP1
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|a HLA-B51
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|a NK cells
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|a HLA-B51 Antigen
|2 NLM
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|a HLA-B Antigens
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|a Nowatzky, Johannes
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 253(2023) vom: 20. Aug., Seite 109661
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|x 1521-7035
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|g volume:253
|g year:2023
|g day:20
|g month:08
|g pages:109661
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