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01000naa a22002652 4500 |
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NLM357656008 |
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DE-627 |
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20231226073050.0 |
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cr uuu---uuuuu |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109656
|2 doi
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2 |
|a pubmed24n1192.xml
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|a (DE-627)NLM357656008
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|a (NLM)37263519
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|a (PII)S1521-6616(23)00419-9
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Sato, Tomohito
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Increase in the number of new cases of ANCA-associated vasculitis in the COVID-19 vaccine era
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| 264 |
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1 |
|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 15.06.2023
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|a Date Revised 21.06.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2023 Elsevier Inc. All rights reserved.
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|a Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune vasculitis characterized by the production of antibodies against ANCA, with unclear pathogenesis. With the ongoing COVID-19 pandemic, COVID-19 mRNA vaccination has been available in Japan since February 2021. Although autoimmune symptoms have been reported after COVID-19 vaccinations, there have been no clinical investigations regarding the relationship between COVID-19 mRNA vaccines and the pathogenesis of AAV. Thus, the present study aimed to investigate whether the administration of COVID-19 mRNA vaccines affects the development of AAV. The study identified patients with new-onset AAV who were MPO-ANCA or PR3-ANCA positive and met the entry criteria of the AAV EMA classification algorithm. The study compared the number of new AAV cases per year before and after the start of the COVID-19 mRNA vaccine program in Japan. The study found that the annual number of new cases of AAV in Japan's Nagasaki Prefecture increased by approximately 1.5-fold since the COVID-19 vaccine program was initiated, suggesting a possible link between the COVID-19 mRNA vaccines and the development of AAV. Although the study provides insight into the clinical evaluation and management of autoimmune symptoms following COVID-19 vaccination, further investigation of the possible association between COVID-19 mRNA vaccines and the pathogenesis of AAV is required
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| 650 |
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4 |
|a Case Reports
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4 |
|a Letter
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a ANCA associated vasculitis
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| 650 |
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4 |
|a COVID-19
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| 650 |
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|a Vaccine
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| 650 |
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7 |
|a COVID-19 Vaccines
|2 NLM
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| 650 |
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|a Antibodies, Antineutrophil Cytoplasmic
|2 NLM
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| 650 |
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7 |
|a Myeloblastin
|2 NLM
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| 650 |
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7 |
|a EC 3.4.21.76
|2 NLM
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| 650 |
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7 |
|a Peroxidase
|2 NLM
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| 650 |
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7 |
|a EC 1.11.1.7
|2 NLM
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| 700 |
1 |
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|a Umeda, Masataka
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sato, Shuntaro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Michitsuji, Toru
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shimizu, Toshimasa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Koga, Tomohiro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Furuse, Yuki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kawakami, Atsushi
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 252(2023) vom: 15. Juli, Seite 109656
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:252
|g year:2023
|g day:15
|g month:07
|g pages:109656
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2023.109656
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 252
|j 2023
|b 15
|c 07
|h 109656
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