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|a 10.1134/S1070363223040199
|2 doi
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|a eng
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|a Taj, M B
|e verfasserin
|4 aut
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|a Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents
|b Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Revised 02.11.2023
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © Pleiades Publishing, Ltd. 2023.
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|a Mechanochemistry is an eco-friendly and solventless method. In the present study, the surface of a custom-made closed mortar and pestle is used as a catalyst to synthesize thiazolidinone-triazole derivatives successfully. The compounds were subjected to potential antidiabetic activity. The results showed that para-chloro-substituted derivative (9c) is most active with IC50 values of 10±1.56. All three compounds 9a-9c with a maximum of 20% inhibition for ALR1 represent superior selectivity toward the targeted ALR2 to act as a lead in the search for new antidiabetic agents
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|a Journal Article
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|a CuAAC reaction
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|a antidiabetic potential
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|a molecular docking
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|a surface scratching
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| 650 |
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4 |
|a thiazole derivatives
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| 700 |
1 |
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|a Raheel, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Alelwani, W
|e verfasserin
|4 aut
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| 700 |
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|a Alnajeebi, A M
|e verfasserin
|4 aut
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| 700 |
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|a Alnoman, R B
|e verfasserin
|4 aut
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|a Javed, T
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Russian journal of general chemistry
|d 1998
|g 93(2023), 4 vom: 24., Seite 912-919
|w (DE-627)NLM098237942
|x 1070-3632
|7 nnas
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| 773 |
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|g volume:93
|g year:2023
|g number:4
|g day:24
|g pages:912-919
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| 856 |
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|u http://dx.doi.org/10.1134/S1070363223040199
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