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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1111/vcp.13227
|2 doi
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5 |
2 |
|a pubmed24n1191.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Hayes, Allison M
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Multiple myeloma presenting as blepharitis in a horse
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| 264 |
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1 |
|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 12.09.2023
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| 500 |
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|a Date Revised 12.09.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a © 2023 American Society for Veterinary Clinical Pathology.
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| 520 |
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|a Myeloma-related disorders, including multiple myeloma, extramedullary plasmacytoma, and solid osseous plasmacytoma, are rare in horses. Clinical complaints for myeloma-related disorders are nonspecific, and when present, M-protein location is more variable on protein electrophoresis in horses relative to dogs and cats. Here, we describe a case of a 15-year-old Thoroughbred mare who presented with recurrent blepharitis. Marked hyperglobulinemia was an incidental finding on routine hematologic and biochemical testing. Bone marrow aspiration consisted of >30% plasma cells, and serum protein electrophoresis demonstrated a monoclonal gammopathy in the alpha 2 fraction leading to a diagnosis of multiple myeloma. Immunofixation and radial immunodiffusion confirmed the presence of an IgG M-protein. Based on a restricted peak in the alpha 2 location, the specific M-protein is suspected to be IgG(T), an IgG isotype unique to horses. M-protein migration in horses is variable relative to dogs and cats, yet immunofixation can still be used to identify equine IgG M-protein isotypes. The unique clinical presentation in this case also serves as a reminder to consider neoplasia in horses with unusual or nonspecific clinical signs
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| 650 |
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4 |
|a Case Reports
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| 650 |
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4 |
|a bone marrow
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| 650 |
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4 |
|a equine
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| 650 |
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4 |
|a hyperglobulinemia
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| 650 |
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4 |
|a immunofixation
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| 650 |
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4 |
|a plasma cell
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| 650 |
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4 |
|a serum protein electrophoresis
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| 650 |
|
7 |
|a Immunoglobulin G
|2 NLM
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| 700 |
1 |
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|a Kastl, Brandy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Perry, Elizabeth
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Moore, A Russell
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Springer, Nora L
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 52(2023), 3 vom: 28. Sept., Seite 514-520
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnns
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| 773 |
1 |
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|g volume:52
|g year:2023
|g number:3
|g day:28
|g month:09
|g pages:514-520
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| 856 |
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0 |
|u http://dx.doi.org/10.1111/vcp.13227
|3 Volltext
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