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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202301479
|2 doi
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|a pubmed24n1191.xml
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|a (DE-627)NLM357461940
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|a (NLM)37243974
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Zhang, Yucai
|e verfasserin
|4 aut
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|a Tumor Eradication by Boron Neutron Capture Therapy with 10 B-enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(Glycerol)
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 04.09.2023
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|a Date Revised 04.09.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10 B carriers with facile preparation as well as advantageous pharmacokinetic and therapeutic profiles. Herein, the design and preparation of sub-10 nm 10 B-enriched hexagonal boron nitride nanoparticles grafted with poly(glycerol) (h-10 BN-PG), and their application to cancer treatment by BNCT are reported. By virtue of their small particle size and outstanding stealth property, h-10 BN-PG nanoparticles accumulate efficiently in murine CT26 colon tumors with a high intratumor 10 B concentration of 8.8%ID g-1 or 102.1 µg g-1 at 12 h post-injection. Moreover, h-10 BN-PG nanoparticles penetrate into the inside of the tumor parenchyma and then are taken up by the tumor cells. BNCT comprising a single bolus injection of h-10 BN-PG nanoparticles and subsequent one-time neutron irradiation results in significant shrinkage of subcutaneous CT26 tumors. h-10 BN-PG-mediated BNCT not only causes direct DNA damage to the tumor cells, but also triggers pronounced inflammatory immune response in the tumor tissues, which contributes to long-lasting tumor suppression after the neutron irradiation. Thus, the h-10 BN-PG nanoparticles are promising BNCT agents to eradicate tumor through highly efficient 10 B accumulation
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|a Journal Article
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|a boron neutron capture therapy
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|a boron nitride nanoparticles
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|a poly(glycerol)
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|a stealth property
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|a tumor eradication
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|a boron nitride
|2 NLM
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| 650 |
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|a 2U4T60A6YD
|2 NLM
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|a Glycerol
|2 NLM
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|a PDC6A3C0OX
|2 NLM
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| 700 |
1 |
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|a Kang, Heon Gyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Hua-Zhen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Honghui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Suzuki, Minoru
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lan, Qing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Komatsu, Naoki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Li
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 35 vom: 27. Sept., Seite e2301479
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:35
|g year:2023
|g number:35
|g day:27
|g month:09
|g pages:e2301479
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|u http://dx.doi.org/10.1002/adma.202301479
|3 Volltext
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