Lubricated Interfaces Enabling Simultaneous Pulsatile and Continuous Chemical Release Modes
© 2023 Wiley-VCH GmbH.
| Veröffentlicht in: | Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 31 vom: 01. Aug., Seite e2302264 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2023
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| Zugriff auf das übergeordnete Werk: | Advanced materials (Deerfield Beach, Fla.) |
| Schlagworte: | Journal Article continuous release liquid crystals lubricated interfaces porous coatings pulsatile release Anti-Bacterial Agents Tetracycline F8VB5M810T Water |
| Zusammenfassung: | © 2023 Wiley-VCH GmbH. The release of chemicals following either pulsatile or continuous release modes is important for various potential applications, including programmed chemical reactions, mechanical actuation, and treatments of various diseases. However, the simultaneous application of both modes in a single material system has been challenging. Here, two chemical loading methods are reported in a liquid-crystal-infused porous surface (LCIPS) that enables both a pulsatile and continuous release of chemicals simultaneously. Specifically, chemicals loaded in the porous substrate exhibit a liquid crystal (LC) mesophase-dependent continuous release, whereas the chemicals dissolved in micrometer-sized aqueous droplets dispersed in the LC surface follow a pulsatile release activated by a phase transition. Moreover, the loading method of distinct molecules can be controlled to program their release mode. Finally, the pulsatile and continuous release of two distinct bioactive small molecules, tetracycline and dexamethasone, are demonstrated which display antibacterial and immunomodulatory activities for applications such as chronic wound healing and biomedical implant coating |
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| Beschreibung: | Date Completed 04.08.2023 Date Revised 04.08.2023 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.202302264 |