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20231226071919.0 |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109648
|2 doi
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|a pubmed24n1190.xml
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|a (DE-627)NLM357123115
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|a (NLM)37209806
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|a (PII)S1521-6616(23)00147-X
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a El Filaly, Hajar
|e verfasserin
|4 aut
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| 245 |
1 |
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|a CXCL-8 as a signature of severe Helicobacter pylori infection and a stimulator of stomach region-dependent immune response
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 22.06.2023
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|a Date Revised 22.06.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023. Published by Elsevier Inc.
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|a Helicobacter pylori infection is involved in development of diverse gastro-pathologies. Our aim is to investigate potential signature of cytokines-chemokine levels (IL-17A, IL-1β, and CXCL-8) in H. pylori-infected patients and their impact on immune response in both corpus and antrum. Multivariate level analysis with machine learning model were carried out using cytokines/chemokine levels of infected Moroccan patients. In addition, Geo dataset was used to run enrichment analysis following CXCL-8 upregulation. Our analysis showed that combination of cytokines-chemokine levels allowed prediction of positive H. pylori density score with <5% of miss-classification error, with fundus CXCL-8 being the most important variable for this discrimination. Furthermore, CXCL-8 dependent expression profile was mainly associated to IL6/JAK/STAT3 signaling in the antrum, interferons alpha and gamma responses in the corpus and commonly induced transcriptional /proliferative activities. To conclude, CXCL-8 level might be a signature of Moroccan H. pylori-infected patients and an inducer of regional-dependent immune response at the gastric level. Larger trials must be carried out to validate the relevance of these results for diverse populations
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Artificial intelligence model
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|a Bioinformatics
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|a CXCL-8
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|a Gastric regionalization
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|a H. pylori
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| 650 |
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|a Immune response
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a CXCL8 protein, human
|2 NLM
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| 700 |
1 |
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|a Desterke, Christophe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Outlioua, Ahmed
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Badre, Wafaa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rabhi, Moncef
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Karkouri, Mehdi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Riyad, Myriam
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Khalil, Abdelouahed
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Arnoult, Damien
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Akarid, Khadija
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 252(2023) vom: 25. Juli, Seite 109648
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:252
|g year:2023
|g day:25
|g month:07
|g pages:109648
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2023.109648
|3 Volltext
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