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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109649
|2 doi
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|a pubmed24n1190.xml
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|a (DE-627)NLM357123093
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|a (NLM)37209805
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|a (PII)S1521-6616(23)00148-1
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Inaba, Masako
|e verfasserin
|4 aut
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|a Antigen-specific T cell balance reveals Why patients with atopic dermatitis fail to achieve immune tolerance
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 15.06.2023
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|a Date Revised 21.06.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 Elsevier Inc. All rights reserved.
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|a The number of regulatory T cells (Tregs) and how they behave in the pathogenesis of atopic dermatitis (AD) are still controversial. We identified and quantified Tregs, mite-specific Tregs, and mite-specific effector T cells (Teffs) in patients with AD and healthy controls (HCs). We collected peripheral blood and analyzed the cells using flow cytometry after stimulation with mite antigens. Mite-specific Tregs and mite-specific Teffs were recognized by the expression of CD137 and CD154, respectively. Patients with AD had more Tregs than HCs; however, when focusing on a single antigen, the ratio of mite-specific Tregs/Teffs was lower in patients with AD than in HCs. Furthermore, the mite-specific Teffs in patients with AD were more likely to produce proinflammatory cytokines interleukin (IL)-4 and IL-13. This Teff-dominant imbalance is thought to be the cause of development of atopic status in patients with AD without immune tolerance
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antigen specificity
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|a Atopic dermatitis
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|a CD137
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|a CD154
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| 650 |
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|a Mite antigen
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|a Regulatory T cell
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|a Antigens
|2 NLM
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| 650 |
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|a Cytokines
|2 NLM
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| 700 |
1 |
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|a Fukushima, Hiroko
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hara, Monami
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hosaka, Sho
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fujiyama, Satoshi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maruo, Kazushi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nomura, Toshifumi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Okiyama, Naoko
|e verfasserin
|4 aut
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| 700 |
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|a Takada, Hidetoshi
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 252(2023) vom: 25. Juli, Seite 109649
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:252
|g year:2023
|g day:25
|g month:07
|g pages:109649
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|u http://dx.doi.org/10.1016/j.clim.2023.109649
|3 Volltext
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