The design of synthetic gene circuits in plants : new components, old challenges

Bibliographische Detailangaben
Veröffentlicht in:	Journal of experimental botany. - 1985. - 74(2023), 13 vom: 18. Juli, Seite 3791-3805
1. Verfasser:	Vazquez-Vilar, Marta (VerfasserIn)
Weitere Verfasser:	Selma, Sara, Orzaez, Diego
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2023
Zugriff auf das übergeordnete Werk:	Journal of experimental botany
Schlagworte:	Review Journal Article Research Support, Non-U.S. Gov't Actuator CRISPRa logic gates plant synthetic biology processor sensor synthetic gene circuits

Beschreibung
Zusammenfassung:	© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Experimental Biology. The fascination produced by the possibility of engineering plants with augmented capabilities has accompanied plant biotechnology since its origins. This prospect has become even more relevant in present times under the pressure imposed by climate change and population growth. Today's plant biotechnologists approach this challenge with the tools of synthetic biology, which facilitate the assembly of synthetic gene circuits (SGCs) from their modular components. Transcriptional SGCs take environmental or endogenous inputs and operate them using transcriptional signals in ways that do not necessarily occur in nature, generating new physiological outputs. Many genetic components have been developed over the years that can be employed in the design and construction of plant SGCs. This review aims to provide an updated view of the components available, proposing a general scheme that facilitates the classification of circuit components in sensor, processor, and actuator modules. Following this analogy, we review the latest advances in the design of SGCs and discuss the main challenges ahead
Beschreibung:	Date Completed 21.07.2023 Date Revised 24.07.2023 published: Print Citation Status MEDLINE
ISSN:	1460-2431
DOI:	10.1093/jxb/erad167