Induction of Tumor Ferroptosis-Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel

Induction of Tumor Ferroptosis-Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel

© 2023 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 35 vom: 17. Sept., Seite e2303542
1. Verfasser: Dai, Xiaomeng (VerfasserIn)
Weitere Verfasser: Zhang, Jia, Bao, Xuanwen, Guo, Yixuan, Jin, Yuzhi, Yang, Chenjing, Zhang, Hangyu, Liu, Lulu, Gao, Yang, Ye, Chanqi, Wu, Wei, Liu, Chuan, Zhao, Chun-Xia, Sheng, Jianpeng, Ren, En, Li, Hongjun, Fang, Weijia, Wu, Baiheng, Ruan, Jian, Gu, Zhen, Chen, Dong, Zhao, Peng
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article cancer immunotherapy drug delivery ferroptosis immune checkpoint blockade
Beschreibung
Zusammenfassung:© 2023 Wiley-VCH GmbH.
The combination of ferroptosis inducers and immune checkpoint blockade can enhance antitumor effects. However, the efficacy in tumors with low immunogenicity requires further investigation. In this work, a water-in-oil Pickering emulsion gel is developed to deliver (1S, 3R)-RSL-3 (RSL-3), a ferroptosis inducer dissolved in iodized oil, and programmed death-1 (PD-1) antibody, the most commonly used immune checkpoint inhibitor dissolved in water, with optimal characteristics (RSL-3 + PD-1gel). Tumor lipase degrades the continuous oil phase, which results in the slow release of RSL-3 and PD-1 antibody and a notable antitumor effect against low-immunogenic hepatocellular carcinoma and pancreatic cancer. Intriguingly, the RSL-3 + PD-1@gel induces ferroptosis of tumor cells, resulting in antitumor immune response via accumulation of helper T lymphocyte cells and cytotoxic T cells. Additionally, the single-cell sequence profiling analysis during tumor treatment reveals the induction of ferroptosis in tumor cells together with strong antitumor immune response in ascites
Beschreibung:Date Revised 01.09.2023
published: Print-Electronic
Citation Status Publisher
ISSN:1521-4095
DOI:10.1002/adma.202303542