Molecular Insights into the Improved Bioactivity of Interferon Conjugates Attached to a Helical Polyglutamate
Attaching polymers, especially polyethylene glycol (PEG), to protein drugs has emerged as a successful strategy to prolong circulation time in the bloodstream. The hypothesis is that the flexible chain wobbles on the protein's surface, thus resisting potential nonspecific adsorption. Such a the...
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Bibliographische Detailangaben
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1999. - 39(2023), 18 vom: 09. Mai, Seite 6539-6547
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| 1. Verfasser: |
Shen, Zhuanglin
(VerfasserIn) |
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| Weitere Verfasser: |
Sun, Yiming,
Zhu, Guoliang,
Xu, Gaixia,
Yu, Zhenqiang,
Lu, Hua,
Chen, Yantao |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2023
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
Interferons
9008-11-1
Polyglutamic Acid
25513-46-6
Polyethylene Glycols
3WJQ0SDW1A
Polymers
Proteins |
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