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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202211055
|2 doi
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|a pubmed24n1187.xml
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|a (DE-627)NLM356183009
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|a (NLM)37114725
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Wang, Xuhui
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Albumin-Hitchhiking Drug Delivery to Tumor-Draining Lymph Nodes Precisely Boosts Tumor-Specific Immunity through Autophagy Modulation of Immune Cells
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 21.07.2023
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|a Date Revised 21.07.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Tumor-draining lymph nodes (TDLNs) are the first sites where tumor components reach and dendritic cells (DCs) present tumor-associated antigens to T cells. DCs rely on autophagy to process tumor antigens into epitope peptides to form epitope-MHC complexes. Selective delivery of autophagy-stimulating drugs to TDLNs may be a precise strategy to boost chemotherapy-induced antitumor immunity. Here, a multistage stimulating strategy is proposed to activate the antitumor immunity cascade by inducing immunogenic death of tumor cells and elevating antigen presentation of DCs in TDLNs. A tumor-microenvironment-responsive "albumin-hitchhiking" micelle is established by self-assembling tumor-targeting oxaliplatin prodrug and lipophilized trehalose prodrug. This demonstrates that lipophilic modification of trehalose with a DSPE tail and the precise exposure in the tumor site enhances its binding to endogenous albumin and realizes TDLNs-selective reflux, where it upregulates antigen processing and presentation of DCs. This study introduces an approach for targeted delivery to TDLNs and provides insights into mechanisms of autophagy in tumor-specific immunity
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|a Journal Article
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4 |
|a antitumor immunity
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4 |
|a autophagy activation
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| 650 |
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4 |
|a chemoimmunotherapy
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| 650 |
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4 |
|a dendritic cells
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| 650 |
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4 |
|a micelles
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| 650 |
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4 |
|a tumor-draining lymph nodes
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| 650 |
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7 |
|a Prodrugs
|2 NLM
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| 650 |
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|a Trehalose
|2 NLM
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| 650 |
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7 |
|a B8WCK70T7I
|2 NLM
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| 650 |
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7 |
|a Albumins
|2 NLM
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| 650 |
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7 |
|a Epitopes
|2 NLM
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| 700 |
1 |
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|a Chen, Dong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Kexin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Man
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhan, Changyou
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, Ziyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deng, Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ren, Kebai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qiu, Yue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zhirong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Qin
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 29 vom: 28. Juli, Seite e2211055
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
8 |
|g volume:35
|g year:2023
|g number:29
|g day:28
|g month:07
|g pages:e2211055
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| 856 |
4 |
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|u http://dx.doi.org/10.1002/adma.202211055
|3 Volltext
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|a AR
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|d 35
|j 2023
|e 29
|b 28
|c 07
|h e2211055
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