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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202300756
|2 doi
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|a pubmed24n1186.xml
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|a eng
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|a Größbacher, Gabriel
|e verfasserin
|4 aut
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|a Volumetric Printing Across Melt Electrowritten Scaffolds Fabricates Multi-Material Living Constructs with Tunable Architecture and Mechanics
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|c 2023
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 14.08.2023
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|a Date Revised 14.08.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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|a Major challenges in biofabrication revolve around capturing the complex, hierarchical composition of native tissues. However, individual 3D printing techniques have limited capacity to produce composite biomaterials with multi-scale resolution. Volumetric bioprinting recently emerged as a paradigm-shift in biofabrication. This ultrafast, light-based technique sculpts cell-laden hydrogel bioresins into 3D structures in a layerless fashion, providing enhanced design freedom over conventional bioprinting. However, it yields prints with low mechanical stability, since soft, cell-friendly hydrogels are used. Herein, the possibility to converge volumetric bioprinting with melt electrowriting, which excels at patterning microfibers, is shown for the fabrication of tubular hydrogel-based composites with enhanced mechanical behavior. Despite including non-transparent melt electrowritten scaffolds in the volumetric printing process, high-resolution bioprinted structures are successfully achieved. Tensile, burst, and bending mechanical properties of printed tubes are tuned altering the electrowritten mesh design, resulting in complex, multi-material tubular constructs with customizable, anisotropic geometries that better mimic intricate biological tubular structures. As a proof-of-concept, engineered tubular structures are obtained by building trilayered cell-laden vessels, and features (valves, branches, fenestrations) that can be rapidly printed using this hybrid approach. This multi-technology convergence offers a new toolbox for manufacturing hierarchical and mechanically tunable multi-material living structures
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|a Journal Article
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|a biofabrication
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|a bioprinting hydrogels
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|a melt electrowriting
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|a volumetric additive manufacturing
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|a Biocompatible Materials
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|a Hydrogels
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|a Bartolf-Kopp, Michael
|e verfasserin
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|a Gergely, Csaba
|e verfasserin
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|a Bernal, Paulina Núñez
|e verfasserin
|4 aut
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|a Florczak, Sammy
|e verfasserin
|4 aut
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|a de Ruijter, Mylène
|e verfasserin
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|a Rodriguez, Núria Ginés
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|a Groll, Jürgen
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|a Malda, Jos
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|a Jungst, Tomasz
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|a Levato, Riccardo
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|4 aut
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|g 35(2023), 32 vom: 02. Aug., Seite e2300756
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|u http://dx.doi.org/10.1002/adma.202300756
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