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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erad145
|2 doi
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|a pubmed25n1186.xml
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|a (DE-627)NLM355899965
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|a (NLM)37086267
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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|a Wang, Bingsen
|e verfasserin
|4 aut
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|a Protein phosphatase StTOPP6 negatively regulates potato bacterial wilt resistance by modulating MAPK signaling
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.08.2023
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|a Date Revised 07.08.2023
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a Potato (Solanum tuberosum) is an important crop globally and is grown across many regions in China, where it ranks fourth in the list of staple foods. However, its production and quality are severely affected by bacterial wilt caused by Ralstonia solanacearum. In this study, we identified StTOPP6, which belongs to the type one protein phosphatase (TOPP) family, and found that transient knock down of StTOPP6 in potato increased resistance against R. solanacearum. RNA-seq analysis showed that knock down of StTOPP6 activated immune responses, and this defense activation partly depended on the mitogen-activated protein kinase (MAPK) signal pathway. StTOPP6 inhibited the expression of StMAPK3, while overexpression of StMAPK3 enhanced resistance to R. solanacearum, supporting the negative role of StTOPP6 in plant immunity. Consistent with the results of knock down of StTOPP6, overexpressing the phosphatase-dead mutation StTOPP6m also attenuated infection and up-regulated MAPK3, showing that StTOPP6 activity is required for disease. Furthermore, we found that StTOPP6 affected the StMAPK3-mediated downstream defense pathway, eventually suppressing the accumulation of reactive oxygen species (ROS). Consistent with these findings, plants with knock down of StTOPP6, overexpression of StTOPP6m, and overexpression of StMAPK3 all displayed ROS accumulation and enhanced resistance to R. solanacearum. Taken together, the findings of our study demonstrate that StTOPP6 negatively regulates resistance to bacterial wilt by affecting the MAPK3-mediated pathway
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Ralstonia solanacearum
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|a Solanum tuberosum
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|a Bacterial wilt
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|a MAPK
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|a StTOPP6
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|a disease resistance
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|a potato
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|a protein phosphatase
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| 650 |
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|a Mitogen-Activated Protein Kinases
|2 NLM
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| 650 |
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|a EC 2.7.11.24
|2 NLM
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| 650 |
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|a Reactive Oxygen Species
|2 NLM
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| 650 |
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|a Phosphoprotein Phosphatases
|2 NLM
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| 650 |
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|a EC 3.1.3.16
|2 NLM
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| 700 |
1 |
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|a Huang, Mengshu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Wenfeng
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Yuqi
|e verfasserin
|4 aut
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|a Yu, Liu
|e verfasserin
|4 aut
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|a Zhou, Dan
|e verfasserin
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|a Meng, Chengzhen
|e verfasserin
|4 aut
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|a Cheng, Dong
|e verfasserin
|4 aut
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|a Qiu, Huishan
|e verfasserin
|4 aut
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|a Tan, Xiaodan
|e verfasserin
|4 aut
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|a Song, Botao
|e verfasserin
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|a Chen, Huilan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 74(2023), 14 vom: 03. Aug., Seite 4208-4224
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnas
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| 773 |
1 |
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|g volume:74
|g year:2023
|g number:14
|g day:03
|g month:08
|g pages:4208-4224
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|u http://dx.doi.org/10.1093/jxb/erad145
|3 Volltext
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