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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202301349
|2 doi
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|a pubmed24n1186.xml
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|a DE-627
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|a eng
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| 100 |
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|a Jin, Lulu
|e verfasserin
|4 aut
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|a Microenvironment-Activated Nanozyme-Armed Bacteriophages Efficiently Combat Bacterial Infection
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|c 2023
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 28.07.2023
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|a Date Revised 28.07.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Bacterial infection is one of the greatest challenges to public health, requiring new therapeutic methods. Herein, an innovative nanozyme-armed phage (phagepalladium (Pd)) system is fabricated for combating bacterial infection. The proposed phage@Pd preserves the function of the phages to achieve precise recognition and adhesion to the host Escherichia coli. In aid of the phages, the ultrasmall Pd nanozymes equipped with conspicuous pH-dependent peroxidase-like activity can generate toxic hydroxyl radical around the bacteria in acidic and hydrogen-peroxide-overexpressed infection microenvironment while remaining inert in physiological conditions, thus realizing the noteworthy elimination of bacteria at infected sites, and in the meantime ensuring the biological safety of phage@Pd in healthy tissues. In addition, the filamentous structure of phage@Pd can also enhance its bactericidal efficiency toward nonhost bacteria by randomly entangling on them, indicating possible broad-spectrum germicidal efficacy. Notably, phage@Pd can not only eradicate planktonic bacteria, but also kill the bacteria inside the biofilm in vitro. For both in vivo models of acute bacterial pneumonia or subcutaneous abscess, phage@Pd shows significant activity in eliminating infection and promoting tissue recovery. These results demonstrate that the phage@Pd nanohybrid is a safe and effective antimicrobial agent, providing a new insight into development of advanced antibacterial materials
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|a Journal Article
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|a antibacterial materials
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|a biohybrid nanomaterials
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|a microenvironment activation
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| 650 |
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|a nanozymes
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|a phages
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|a Anti-Bacterial Agents
|2 NLM
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| 700 |
1 |
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|a Cao, Fangfang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Yong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Chenyin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qian, Zhefeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jiaojiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mao, Zhengwei
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 30 vom: 12. Juli, Seite e2301349
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|g year:2023
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|g pages:e2301349
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|u http://dx.doi.org/10.1002/adma.202301349
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