Reduced quantity and function of pneumococcal antibodies are associated with exacerbations of COPD in SPIROMICS

Reduced quantity and function of pneumococcal antibodies are associated with exacerbations of COPD in SPIROMICS

Copyright © 2023 Elsevier Inc. All rights reserved.

Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 250(2023) vom: 15. Mai, Seite 109324
Auteur principal: LaFon, David C (Auteur)
Autres auteurs: Woo, Han, Fedarko, Neal, Azar, Antoine, Hill, Harry, Tebo, Anne E, Martins, Thomas B, Han, MeiLan K, Krishnan, Jerry A, Ortega, Victor E, Barjaktarevic, Igor, Kaner, Robert J, Hastie, Annette, O'Neal, Wanda K, Couper, David, Woodruff, Prescott G, Curtis, Jeffrey L, Hansel, Nadia N, Nahm, Moon H, Dransfield, Mark T, Putcha, Nirupama, SPIROMICS investigators
Format: Article en ligne
Langue:English
Publié: 2023
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Antibodies Immunity Immunoglobulin G Opsonization Streptococcus pneumoniae Antibodies, Bacterial Pneumococcal Vaccines
Description
Résumé:Copyright © 2023 Elsevier Inc. All rights reserved.
While hypogammaglobulinemia is associated with COPD exacerbations, it is unknown whether frequent exacerbators have specific defects in antibody production/function. We hypothesized that reduced quantity/function of serum pneumococcal antibodies correlate with exacerbation risk in the SPIROMICS cohort. We measured total pneumococcal IgG in n = 764 previously vaccinated participants with COPD. In a propensity-matched subset of n = 200 with vaccination within five years (n = 50 without exacerbations in the previous year; n = 75 with one, n = 75 with ≥2), we measured pneumococcal IgG for 23 individual serotypes, and pneumococcal antibody function for 4 serotypes. Higher total pneumococcal IgG, serotype-specific IgG (17/23 serotypes), and antibody function (3/4 serotypes) were independently associated with fewer prior exacerbations. Higher pneumococcal IgG (5/23 serotypes) predicted lower exacerbation risk in the following year. Pneumococcal antibodies are inversely associated with exacerbations, supporting the presence of immune defects in frequent exacerbators. With further study, pneumococcal antibodies may be useful biomarkers for immune dysfunction in COPD
Description:Date Completed 28.04.2023
Date Revised 23.09.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109324