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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202301283
|2 doi
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|a pubmed25n1184.xml
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|a (DE-627)NLM355343142
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|a (NLM)37029662
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Duan, Ruixue
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Reversing Acute Kidney Injury through Coordinated Interplay of Anti-Inflammation and Iron Supplementation
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 17.07.2023
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|a Date Revised 18.07.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Acute kidney injury (AKI) induced by ischemia reperfusion is closely related to mitochondrial dysfunction. Nicotinamide adenine dinucleotide (NAD+ ) can enhance the mitochondrial function and restrain the following inflammation, but it is hardly delivered and lacks renal targeting ability. To address these problems, herein, an ultrasmall Fe3 O4 nanoparticle is used as a carrier to deliver nicotinamide mononucleotide (NMN), a precursor of NAD+ . An outstanding sophistication of the current design is that once NMN is attached on the surface of Fe3 O4 nanoparticles through its phosphate group, the remaining part is structurally highly similar to nicotinamide riboside, which provides an opportunity to deliver the NAD+ precursor into renal cells through nicotinamide riboside kinase 1 on the cell membrane. It is demonstrated that NMN-loaded Fe3 O4 nanoparticles can effectively reverse AKI induced by ischemia reperfusion. In-depth studies indicate that a well-timed iron replenishment following anti-inflammation treatment plays a determined role in recovering AKI, which distinguishes the current study from previous strategies centering on anti-ROS (reactive oxygen species), anti-inflammation, or even iron elimination
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|a Journal Article
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|a acute kidney injury
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| 650 |
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4 |
|a anti-inflammation
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| 650 |
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4 |
|a iron oxide nanoparticles
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| 650 |
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4 |
|a iron supplementation
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| 650 |
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4 |
|a red blood cells
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| 650 |
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|a NAD
|2 NLM
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| 650 |
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7 |
|a 0U46U6E8UK
|2 NLM
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| 650 |
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7 |
|a Nicotinamide Mononucleotide
|2 NLM
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| 650 |
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7 |
|a 1094-61-7
|2 NLM
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| 650 |
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7 |
|a Reactive Oxygen Species
|2 NLM
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| 650 |
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7 |
|a Anti-Inflammatory Agents
|2 NLM
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| 700 |
1 |
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|a Li, Yueping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Ruru
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Xuelan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeng, Jianfeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Mingyuan
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 28 vom: 03. Juli, Seite e2301283
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
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|g volume:35
|g year:2023
|g number:28
|g day:03
|g month:07
|g pages:e2301283
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202301283
|3 Volltext
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