Elevated exosome-transferrable lncRNA EPB41L4A-AS1 in CD56bright NK cells is responsible for the impaired NK function in neuroblastoma patients by suppressing cell glycolysis

Elevated exosome-transferrable lncRNA EPB41L4A-AS1 in CD56bright NK cells is responsible for the impaired NK function in neuroblastoma patients by suppressing cell glycolysis

Copyright © 2023 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 250(2023) vom: 15. Mai, Seite 109322
1. Verfasser: Chai, Wenjia (VerfasserIn)
Weitere Verfasser: Wang, Xiaolin, Lu, Zhengjing, Zhang, Shihan, Wang, Wei, Wang, Hui, Chen, Chenghao, Yang, Wei, Cheng, Haiyan, Wang, Huanmin, Feng, Jun, Yang, Shen, Li, Qiliang, Song, Wenqi, Jin, Fang, Zhang, Hui, Su, Yan, Gui, Jingang
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Exosome Glycolysis LncRNA NK cell subset Neuroblastoma CD56 Antigen RNA, Long Noncoding NCAM1 protein, human
Beschreibung
Zusammenfassung:Copyright © 2023 Elsevier Inc. All rights reserved.
NK cells are one of key immune components in neuroblastoma (NB) surveillance and eradication. Glucose metabolism as a major source of fuel for NK activation is exquisitely regulated. Our data revealed a diminished NK activation and a disproportionally augmented CD56bright subset in NB. Further study showed that NK cells in NB presented with an arrested glycolysis accompanied by an elevated expression of the long noncoding RNA (lncRNA) EPB41L4A-AS1, a known crucial participant in glycolysis regulation, in the CD56bright NK subset. The inhibitory function of lncRNA EPB41L4A-AS1 was recapitulated. Interestingly, our study demonstrated that exosomal lncRNA EPB41L4A-AS1 was transferrable from CD56bright NK to CD56dim NK and was able to quench the glycolysis of target NK. Our data demonstrated that an arrested glycolysis in patient NK cells was associated with an elevated lncRNA in CD56bright NK subset and a cross-talk between heterogeneous NK subsets was achieved by transferring metabolic inhibitory lncRNA through exosomes
Beschreibung:Date Completed 01.05.2023
Date Revised 07.05.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109322