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20231226063612.0 |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109305
|2 doi
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|a pubmed24n1183.xml
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|a (DE-627)NLM355084538
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|a (NLM)37003592
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|a (PII)S1521-6616(23)00084-0
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ryu, Hye-Myung
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Characterization of immune responses associated with ERAP-1 expression in HSV-induced Behçet's disease mouse model
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 01.05.2023
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|a Date Revised 07.05.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023. Published by Elsevier Inc.
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|a Behçet's disease (BD) is a chronic multisystem inflammatory disorder. Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphism has been reported as a risk factor for BD. However, the immunological role of ERAP1 in BD remains unclear. Therefore, the purpose of this study was to investigate the immunological role of ERAP1 in BD using a mouse model. ERAP1 incomplete expressing mice (ERAP1 hetero, +/-) were generated and inoculated with herpes simplex virus 1 to produce a BD mouse model. In these mice, dendritic cell activation markers and other immune response-related markers were analyzed. Among them, the factor showing a significant difference between ERAP1+/- BD mice and WT BD mice was IL-17. In ERAP1+/-, BD had significantly different expression levels of CD80, CD11b, Ly6G, RORγt, IFNγ, and IL-17 compared to asymptomatic controls. This study demonstrates ERAP1 defective expressions play an important role in BD development through inappropriate regulation of Th17
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Behçet's disease
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|a Dendritic cell
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| 650 |
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|a ERAP1
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| 650 |
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|a HSV
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| 650 |
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|a Th17
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| 650 |
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|a Aminopeptidases
|2 NLM
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| 650 |
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|a EC 3.4.11.-
|2 NLM
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| 650 |
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|a ERAP1 protein, human
|2 NLM
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| 650 |
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|a EC 3.4.11.-
|2 NLM
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| 650 |
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|a Interleukin-17
|2 NLM
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| 650 |
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7 |
|a Minor Histocompatibility Antigens
|2 NLM
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| 650 |
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|a ERAP1 protein, mouse
|2 NLM
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| 650 |
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|a EC 3.4.11.-
|2 NLM
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| 700 |
1 |
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|a Islam, S M Shamsul
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sayeed, Hasan M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Babita, Rahar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Seong, Je Kyung
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Ho
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sohn, Seonghyang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 250(2023) vom: 15. Mai, Seite 109305
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:250
|g year:2023
|g day:15
|g month:05
|g pages:109305
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|u http://dx.doi.org/10.1016/j.clim.2023.109305
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 250
|j 2023
|b 15
|c 05
|h 109305
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