Inhibition of Tumor Metastasis by Liquid-Nitrogen-Shocked Tumor Cells with Oncolytic Viruses Infection

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 28 vom: 14. Juli, Seite e2212210
1. Verfasser:	Wu, Qing (VerfasserIn)
Weitere Verfasser:	Huang, Hanwei, Sun, Mengchi, Zhang, Ruizhe, Wang, Junxia, Zheng, Hanqi, Zhu, Chaojie, Yang, Shihua, Shen, Xinyuan, Shi, Jiaqi, Liu, Feng, Wu, Wei, Sun, Jin, Liu, Funan, Li, Hongjun, Gu, Zhen
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2023
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article cancer immunotherapy cell delivery drug delivery metastasis treatment oncolytic virotherapy Cancer Vaccines

Beschreibung
Zusammenfassung:	© 2023 Wiley-VCH GmbH. Despite the superior tumor lytic efficacy of oncolytic viruses (OVs), their systemic delivery still faces the challenges of limited circulating periods, poor tumor tropism, and spontaneous antiviral immune responses. Herein, a virus-concealed tumor-targeting strategy enabling OVs' delivery toward lung metastasis via systemic administration is described. The OVs can actively infect, be internalized, and cloak into tumor cells. Then the tumor cells are subsequently treated with liquid-nitrogen-shocking to eliminate the pathogenicity. Such a Trojan Horse-like vehicle avoids virus neutralization and clearance in the bloodstream and facilitates tumor-targeted delivery for more than 110-fold virus enrichment in the tumor metastasis. In addition, this strategy can serve as a tumor vaccine and initiate endogenous adaptive antitumor effects through increasing the memory T cells and modulating the tumor immune microenvironment, including reducing the M2 macrophage, downregulating Treg cells, and priming T cells
Beschreibung:	Date Completed 17.07.2023 Date Revised 18.07.2023 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202212210