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231226s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202211261
|2 doi
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|a pubmed24n1320.xml
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|a (DE-627)NLM355057816
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|a eng
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| 100 |
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|a Neal, Craig J
|e verfasserin
|4 aut
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|a Surface Chemistry of Biologically Active Reducible Oxide Nanozymes
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 08.03.2024
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|a Date Revised 08.03.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Reducible metal oxide nanozymes (rNZs) are a subject of intense recent interest due to their catalytic nature, ease of synthesis, and complex surface character. Such materials contain surface sites which facilitate enzyme-mimetic reactions via substrate coordination and redox cycling. Further, these surface reactive sites are shown to be highly sensitive to stresses within the nanomaterial lattice, the physicochemical environment, and to processing conditions occurring as part of their syntheses. When administered in vivo, a complex protein corona binds to the surface, redefining its biological identity and subsequent interactions within the biological system. Catalytic activities of rNZs each deliver a differing impact on protein corona formation, its composition, and in turn, their recognition, and internalization by host cells. Improving the understanding of the precise principles that dominate rNZ surface-biomolecule adsorption raises the question of whether designer rNZs can be engineered to prevent corona formation, or indeed to produce "custom" protein coronas applied either in vitro, and preadministration, or formed immediately upon their exposure to body fluids. Here, fundamental surface chemistry processes and their implications in rNZ material performance are considered. In particular, material structures which inform component adsorption from the application environment, including substrates for enzyme-mimetic reactions are discussed
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|a Journal Article
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|a Review
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|a ROS scavenging
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|a cerium oxide
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| 650 |
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4 |
|a nanozyme
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4 |
|a protein corona
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|a reducible oxide
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|a Protein Corona
|2 NLM
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| 650 |
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|a Oxides
|2 NLM
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1 |
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|a Kolanthai, Elayaraja
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wei, Fei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Coathup, Melanie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Seal, Sudipta
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 10 vom: 31. März, Seite e2211261
|w (DE-627)NLM098206397
|x 1521-4095
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|g volume:36
|g year:2024
|g number:10
|g day:31
|g month:03
|g pages:e2211261
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|u http://dx.doi.org/10.1002/adma.202211261
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