Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme-Mediated Catalytic/Starvation/Mild-Temperature Photothermal Therapy

Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme-Mediated Catalytic/Starvation/Mild-Temperature Photothermal Therapy

© 2023 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 22 vom: 01. Juni, Seite e2210464
1. Verfasser: Li, Yongjuan (VerfasserIn)
Weitere Verfasser: Zhang, Yu, Dong, Ya, Akakuru, Ozioma Udochukwu, Yao, Xiaohan, Yi, Jinmeng, Li, Xinyan, Wang, Linlin, Lou, Xiaohan, Zhu, Baoyu, Fan, Kelong, Qin, Zhihai
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article cascade nanozymes catalytic therapy gap junction ablation mild-temperature photothermal therapy tumor starvation Connexins Ferric Compounds Reactive Oxygen Species Hydrogen Peroxide mehr... BBX060AN9V Glucose Oxidase EC 1.1.3.4
LEADER 01000naa a22002652 4500
001 NLM354700197
003 DE-627
005 20231226062759.0
007 cr uuu---uuuuu
008 231226s2023 xx |||||o 00| ||eng c
024 7 |a 10.1002/adma.202210464  |2 doi 
028 5 2 |a pubmed24n1182.xml 
035 |a (DE-627)NLM354700197 
035 |a (NLM)36964940 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Li, Yongjuan  |e verfasserin  |4 aut 
245 1 0 |a Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme-Mediated Catalytic/Starvation/Mild-Temperature Photothermal Therapy 
264 1 |c 2023 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 02.06.2023 
500 |a Date Revised 02.06.2023 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a © 2023 Wiley-VCH GmbH. 
520 |a Reactive oxygen species (ROS)-mediated tumor catalytic therapy is typically hindered by gap junction proteins that form cell-to-cell channels to remove cytotoxic ROS, thereby protecting tumor cells from oxidative damage. In this work, a multifunctional nanozyme, FePGOGA, is designed and prepared by Fe(III)-mediated oxidative polymerization (FeP), followed by glucose oxidase (GOx) and GAP19 peptides co-loading through electrostatic and π-π interactions. The FePGOGA nanozyme exhibits excellent cascade peroxidase- and glutathione-oxidase-like activities that efficiently catalyze hydrogen peroxide conversion to hydroxyl radicals and convert reduced glutathione to oxidized glutathione disulfide. The loaded GOx starves the tumors and aggravates tumor oxidative stress through glucose decomposition, while GAP19 peptides block the hemichannels by inducing degradation of Cx43, thus increasing the accumulation of intracellular ROS, and decreasing the transport of intracellular glucose. Furthermore, the ROS reacts with primary amines of heat shock proteins to destroy their structure and function, enabling tumor photothermal therapy at the widely sought-after mild temperature (mildPTT, ≤45 °C). In vivo experiments demonstrate the significant antitumor effectof FePGOGA on cal27 xenograft tumors under near-infrared light irradiation. This study demonstrates the successful ablation of gap junction proteins to overcome resistance to ROS-mediated therapy, providing a regulator to suppress tumor self-preservation during tumor starvation, catalytic therapy, and mildPTT 
650 4 |a Journal Article 
650 4 |a cascade nanozymes 
650 4 |a catalytic therapy 
650 4 |a gap junction ablation 
650 4 |a mild-temperature photothermal therapy 
650 4 |a tumor starvation 
650 7 |a Connexins  |2 NLM 
650 7 |a Ferric Compounds  |2 NLM 
650 7 |a Reactive Oxygen Species  |2 NLM 
650 7 |a Hydrogen Peroxide  |2 NLM 
650 7 |a BBX060AN9V  |2 NLM 
650 7 |a Glucose Oxidase  |2 NLM 
650 7 |a EC 1.1.3.4  |2 NLM 
700 1 |a Zhang, Yu  |e verfasserin  |4 aut 
700 1 |a Dong, Ya  |e verfasserin  |4 aut 
700 1 |a Akakuru, Ozioma Udochukwu  |e verfasserin  |4 aut 
700 1 |a Yao, Xiaohan  |e verfasserin  |4 aut 
700 1 |a Yi, Jinmeng  |e verfasserin  |4 aut 
700 1 |a Li, Xinyan  |e verfasserin  |4 aut 
700 1 |a Wang, Linlin  |e verfasserin  |4 aut 
700 1 |a Lou, Xiaohan  |e verfasserin  |4 aut 
700 1 |a Zhu, Baoyu  |e verfasserin  |4 aut 
700 1 |a Fan, Kelong  |e verfasserin  |4 aut 
700 1 |a Qin, Zhihai  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 35(2023), 22 vom: 01. Juni, Seite e2210464  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:35  |g year:2023  |g number:22  |g day:01  |g month:06  |g pages:e2210464 
856 4 0 |u http://dx.doi.org/10.1002/adma.202210464  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 35  |j 2023  |e 22  |b 01  |c 06  |h e2210464