Programmable Tissue Folding Patterns in Structured Hydrogels

© 2023 The Authors. Advanced Materials published by Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 43 vom: 25. Okt., Seite e2300017
1. Verfasser: Roy, Avinava (VerfasserIn)
Weitere Verfasser: Zhang, Zenghao, Eiken, Madeline K, Shi, Alan, Pena-Francesch, Abdon, Loebel, Claudia
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article airways hydrogels magnetoactive hydrogels microactuators tissue folding Hydrogels Hyaluronic Acid 9004-61-9 Alginates mehr... Acrylic Resins polyacrylamide 9003-05-8
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520 |a Folding of mucosal tissues, such as the tissue within the epithelium of the upper respiratory airways, is critical for organ function. Studying the influence of folded tissue patterns on cellular function is challenging mainly due to the lack of suitable cell culture platforms that can recreate dynamic tissue folding in vitro. Here, a bilayer hydrogel folding system, composed of alginate/polyacrylamide double-network (DN) and hyaluronic acid (HA) hydrogels, to generate static folding patterns based on mechanical instabilities, is described. By encapsulating human fibroblasts into patterned HA hydrogels, human bronchial epithelial cells form a folded pseudostratified monolayer. Using magnetic microparticles, DN hydrogels reversibly fold into pre-defined patterns and enable programmable on-demand folding of cell-laden hydrogel systems upon applying a magnetic field. This hydrogel construction provides a dynamic culture system for mimicking tissue folding in vitro, which is extendable to other cell types and organ systems 
650 4 |a Journal Article 
650 4 |a airways 
650 4 |a hydrogels 
650 4 |a magnetoactive hydrogels 
650 4 |a microactuators 
650 4 |a tissue folding 
650 7 |a Hydrogels  |2 NLM 
650 7 |a Hyaluronic Acid  |2 NLM 
650 7 |a 9004-61-9  |2 NLM 
650 7 |a Alginates  |2 NLM 
650 7 |a Acrylic Resins  |2 NLM 
650 7 |a polyacrylamide  |2 NLM 
650 7 |a 9003-05-8  |2 NLM 
700 1 |a Zhang, Zenghao  |e verfasserin  |4 aut 
700 1 |a Eiken, Madeline K  |e verfasserin  |4 aut 
700 1 |a Shi, Alan  |e verfasserin  |4 aut 
700 1 |a Pena-Francesch, Abdon  |e verfasserin  |4 aut 
700 1 |a Loebel, Claudia  |e verfasserin  |4 aut 
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