PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS)

PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS)

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 250(2023) vom: 15. Mai, Seite 109296
1. Verfasser: Smith, E M D (VerfasserIn)
Weitere Verfasser: Aggarwal, A (BerichterstatterIn), Ainsworth, J (BerichterstatterIn), Al-Abadi, E (BerichterstatterIn), Avcin, T, Bortey, L, Burnham, J, Ciurtin, C, Hedrich, C M, Kamphuis, S, Lambert, L, Levy, D M, Lewandowski, L, Maxwell, N, Morand, E, Ozen, S, Pain, C E, Ravelli, A, Saad Magalhaes, C, Pilkington, C, Schonenberg-Meinema, D, Scott, C, Tullus, K, Beresford, M W, International cSLE T2T Task Force, Goilav, B, Marks, S, Oni, L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Childhood-SLE Low disease activity T2T Treat-to-target cLLDAS cSLE Immunosuppressive Agents Prednisolone 9PHQ9Y1OLM
Beschreibung
Zusammenfassung:Copyright © 2023. Published by Elsevier Inc.
OBJECTIVE: To achieve a consensus-based definition of Low Disease Activity (LDA) for use in cSLE trials
METHODS: The International cSLE T2T Task Force, comprising of paediatric rheumatologists/nephrologists, and adult rheumatologists undertook a series of Delphi surveys/consensus meetings to discuss, refine, and vote upon cSLE LDA criteria
RESULTS: The Task Force agreed that LDA should be based upon the adult-SLE Lupus Low Disease Activity State definition (LLDAS), with modifications to make it applicable to cSLE (cLLDAS). They agreed upon five cLLDAS criteria: (1) SLE Disease Activity Index (SLEDAI)-2 K ≤4, with no activity in major organ systems; (2) no new features of lupus disease activity compared with the last assessment; (3) Physician Global Assessment score of ≤1 (0-3 scale); (4) prednisolone dose of ≤0.15 mg/kg/day, 7.5 mg/day/maximum; while on (5) stable antimalarials, immunosuppressives, and biologics
CONCLUSIONS: A cSLE-appropriate definition of cLLDAS has been generated, maintaining alignment with the adult-SLE definition to promote life-course research
Beschreibung:Date Completed 28.04.2023
Date Revised 24.09.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109296