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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202209769
|2 doi
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|a pubmed25n1181.xml
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|a (DE-627)NLM354398075
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|a (NLM)36934418
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Bai, Yunyang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Manipulation of Heterogeneous Surface Electric Potential Promotes Osteogenesis by Strengthening RGD Peptide Binding and Cellular Mechanosensing
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 16.06.2023
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|a Date Revised 16.06.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a The heterogeneity of extracellular matrix (ECM) topology, stiffness, and architecture is a key factor modulating cellular behavior and osteogenesis. However, the effects of heterogeneous ECM electric potential at the micro- and nanoscale on osteogenesis remain to be elucidated. Here, the heterogeneous distribution of surface potential is established by incorporating ferroelectric BaTiO3 nanofibers (BTNF) into poly(vinylidene fluoridetrifluoroethylene) (P(VDF-TrFE)) matrix based on phase-field and first-principles simulation. By optimizing the aspect ratios of BTNF fillers, the anisotropic distribution of surface potential on BTNF/P(VDF-TrFE) nanocomposite membranes can be achieved by strong spontaneous electric polarization of BTNF fillers. These results indicate that heterogeneous surface potential distribution leads to a meshwork pattern of fibronectin (FN) aggregation, which increased FN-III7-10 (FN fragment) focal flexibility and anchor points as predicted by molecular dynamics simulation. Furthermore, integrin clustering, focal adhesion formation, cell spreading, and adhesion are enhanced sequentially. Increased traction of actin fibers amplifies mechanotransduction by promoting nuclear translocation of YAP/Runx2, which enhances osteogenesis in vitro and bone regeneration in vivo. The work thus provides fundamental insights into the biological effects of surface potential heterogeneity at the micro- and nanoscale on osteogenesis, and also develops a new strategy to optimize the performance of electroactive biomaterials for tissue regenerative therapies
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|a Journal Article
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|a RGD peptide binding
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|a bone regeneration
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|a mechanotransduction
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|a osteogenic differentiation
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|a surface potential heterogeneity
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|a arginyl-glycyl-aspartic acid
|2 NLM
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| 650 |
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|a 78VO7F77PN
|2 NLM
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|a Fibronectins
|2 NLM
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| 700 |
1 |
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|a Zheng, Xiaona
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhong, Xianwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cui, Qun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Shuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wen, Xiufang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Heng, Boon Chin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Shan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Yang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jinxing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wei, Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deng, Xuliang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xuehui
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 24 vom: 03. Juni, Seite e2209769
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
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|g volume:35
|g year:2023
|g number:24
|g day:03
|g month:06
|g pages:e2209769
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202209769
|3 Volltext
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