Plasma procalcitonin kinetics in healthy dogs and dogs undergoing tibial plateau leveling osteotomy

© 2023 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals LLC on behalf of American Society for Veterinary Clinical Pathology.

Bibliographische Detailangaben
Veröffentlicht in:Veterinary clinical pathology. - 1975. - 52(2023), 2 vom: 31. Juni, Seite 360-368
1. Verfasser: Rompf, Johanna (VerfasserIn)
Weitere Verfasser: Hettlich, Bianca, Lutz, Bérénice, Marti, Eliane, Mirkovitch, Jelena, Peters, Laureen, Adamik, Katja-Nicole, Schüpbach-Regula, Gertraud, Willi, Barbara, Schuller, Simone
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Veterinary clinical pathology
Schlagworte:Journal Article canine interindividual variability intraindividual variability orthopedic surgery surgical site infection Procalcitonin C-Reactive Protein 9007-41-4
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100 1 |a Rompf, Johanna  |e verfasserin  |4 aut 
245 1 0 |a Plasma procalcitonin kinetics in healthy dogs and dogs undergoing tibial plateau leveling osteotomy 
264 1 |c 2023 
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500 |a Date Completed 06.06.2023 
500 |a Date Revised 06.06.2023 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a © 2023 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals LLC on behalf of American Society for Veterinary Clinical Pathology. 
520 |a BACKGROUND: Procalcitonin (PCT) is a well-established biomarker for bacterial infection in human patients 
520 |a OBJECTIVES: We aimed to analyze the kinetics of plasma PCT (pPCT) in healthy dogs and dogs with canine cranial cruciate ligament (CCL) rupture undergoing tibial plateau leveling osteotomy (TPLO) 
520 |a METHODS: This prospective, longitudinal study included 15 healthy dogs and 25 dogs undergoing TPLO. Hematology, pPCT, and C-reactive protein (CRP) were assessed on 3 consecutive days in healthy dogs and 1 day preoperatively and days 1, 2, 10, and 56 postoperatively. Inter- and intraindividual variability of pPCT were assessed in healthy dogs. Median pPCT concentrations of dogs with CCL rupture preoperatively were compared with healthy controls, and median pPCT concentrations, as well as percentage change post anesthesia, arthroscopy, and TPLO, were compared with baseline. For the correlation analysis, the Spearman rank correlation test was used 
520 |a RESULTS: Inter- and intraindividual variabilities of pPCT in healthy dogs were 36% and 15%, respectively. Median baseline pPCT concentrations were not significantly different between healthy dogs (118.9 pg/mL; IQR: 75.3-157.3 pg/mL) and dogs undergoing TPLO (95.9 pg/mL; IQR: 63.8-117.0 pg/mL). Plasma PCT concentrations were significantly lower immediately post- than preoperatively (P < 0.001). CRP, WBC, and neutrophil concentrations increased significantly on post-OP day 2 and had normalized by day 10 
520 |a CONCLUSIONS: These results indicate that CCL rupture, as well as anesthesia, arthroscopy, and TPLO combined, are not associated with increased pPCT concentrations in dogs with uncomplicated recovery. Considering the high intraindividual variability, individual serial measurements rather than a population-based reference interval should be considered 
650 4 |a Journal Article 
650 4 |a canine 
650 4 |a interindividual variability 
650 4 |a intraindividual variability 
650 4 |a orthopedic surgery 
650 4 |a surgical site infection 
650 7 |a Procalcitonin  |2 NLM 
650 7 |a C-Reactive Protein  |2 NLM 
650 7 |a 9007-41-4  |2 NLM 
700 1 |a Hettlich, Bianca  |e verfasserin  |4 aut 
700 1 |a Lutz, Bérénice  |e verfasserin  |4 aut 
700 1 |a Marti, Eliane  |e verfasserin  |4 aut 
700 1 |a Mirkovitch, Jelena  |e verfasserin  |4 aut 
700 1 |a Peters, Laureen  |e verfasserin  |4 aut 
700 1 |a Adamik, Katja-Nicole  |e verfasserin  |4 aut 
700 1 |a Schüpbach-Regula, Gertraud  |e verfasserin  |4 aut 
700 1 |a Willi, Barbara  |e verfasserin  |4 aut 
700 1 |a Schuller, Simone  |e verfasserin  |4 aut 
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773 1 8 |g volume:52  |g year:2023  |g number:2  |g day:31  |g month:06  |g pages:360-368 
856 4 0 |u http://dx.doi.org/10.1111/vcp.13212  |3 Volltext 
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