Neutrophil extracellular trap formation in anti-neutrophil cytoplasmic antibody-associated and large-vessel vasculitis

Neutrophil extracellular trap formation in anti-neutrophil cytoplasmic antibody-associated and large-vessel vasculitis

Copyright © 2023 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 249(2023) vom: 01. Apr., Seite 109274
1. Verfasser: Michailidou, Despina (VerfasserIn)
Weitere Verfasser: Kuley, Runa, Wang, Ting, Hermanson, Payton, Grayson, Peter C, Cuthbertson, David, Khalidi, Nader A, Koening, Curry L, Langford, Carol A, McAlear, Carol A, Moreland, Larry W, Pagnoux, Christian, Seo, Philip, Specks, Ulrich, Sreih, Antoine G, Warrington, Kenneth J, Monach, Paul A, Merkel, Peter A, Lood, Christian
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Anti-neutrophil cytoplasmic antibody associated vasculitis Histone Large vessel vasculitis Neutrophil extracellular traps Neutrophils Platelet activation Thrombospondin-1 Thrombospondin 1
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245 1 0 |a Neutrophil extracellular trap formation in anti-neutrophil cytoplasmic antibody-associated and large-vessel vasculitis 
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520 |a Levels of neutrophil extracellular traps (NETs) were measured in plasma of healthy controls (HC, n = 30) and patients with granulomatosis with polyangiitis (GPA, n = 123), microscopic polyangiitis (MPA, n = 61), Takayasu's arteritis (TAK, n = 58), and giant cell arteritis (GCA, n = 68), at times of remission or activity and correlated with levels of the platelet-derived thrombospondin-1 (TSP-1). Levels of NETs were elevated during active disease in patients with GPA (p < 0.0001), MPA (p = 0.0038), TAK (p < 0.0001), and GCA (p < 0.0001), and in remission for GPA, p < 0.0001, MPA, p = 0.005, TAK, p = 0.03, and GCA, p = 0.0009. All cohorts demonstrated impaired NET degradation. Patients with GPA (p = 0.0045) and MPA (p = 0.005) had anti-NET IgG antibodies. Patients with TAK had anti-histone antibodies (p < 0.01), correlating with presence of NETs. Levels of TSP-1 were increased in all patients with vasculitis, and associated with NET formation. NET formation is a common process in vasculitides. Targeting NET formation or degradation could be potential therapeutic approaches for vasculitides 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Anti-neutrophil cytoplasmic antibody associated vasculitis 
650 4 |a Histone 
650 4 |a Large vessel vasculitis 
650 4 |a Neutrophil extracellular traps 
650 4 |a Neutrophils 
650 4 |a Platelet activation 
650 4 |a Thrombospondin-1 
650 7 |a Thrombospondin 1  |2 NLM 
700 1 |a Kuley, Runa  |e verfasserin  |4 aut 
700 1 |a Wang, Ting  |e verfasserin  |4 aut 
700 1 |a Hermanson, Payton  |e verfasserin  |4 aut 
700 1 |a Grayson, Peter C  |e verfasserin  |4 aut 
700 1 |a Cuthbertson, David  |e verfasserin  |4 aut 
700 1 |a Khalidi, Nader A  |e verfasserin  |4 aut 
700 1 |a Koening, Curry L  |e verfasserin  |4 aut 
700 1 |a Langford, Carol A  |e verfasserin  |4 aut 
700 1 |a McAlear, Carol A  |e verfasserin  |4 aut 
700 1 |a Moreland, Larry W  |e verfasserin  |4 aut 
700 1 |a Pagnoux, Christian  |e verfasserin  |4 aut 
700 1 |a Seo, Philip  |e verfasserin  |4 aut 
700 1 |a Specks, Ulrich  |e verfasserin  |4 aut 
700 1 |a Sreih, Antoine G  |e verfasserin  |4 aut 
700 1 |a Warrington, Kenneth J  |e verfasserin  |4 aut 
700 1 |a Monach, Paul A  |e verfasserin  |4 aut 
700 1 |a Merkel, Peter A  |e verfasserin  |4 aut 
700 1 |a Lood, Christian  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 249(2023) vom: 01. Apr., Seite 109274  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
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856 4 0 |u http://dx.doi.org/10.1016/j.clim.2023.109274  |3 Volltext 
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