Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis

Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 249(2023) vom: 20. Apr., Seite 109277
Auteur principal: Gudmundsdottir, Judith A (Auteur)
Autres auteurs: Thorgeirsdottir, Sigridur, Lundbäck, Veroniqa, Göngrich, Christina, Lingman Framme, Jenny, Kindgren, Erik, Rydenman, Karin, Ludviksson, Bjorn Runar, Bjarnadottir, Helga, Runarsdottir, Saga, Nilsson, Staffan, Zetterström, Rolf H, Ekwall, Olov, Lindgren, Susanne
Format: Article en ligne
Langue:English
Publié: 2023
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Arthritis, juvenile Autoimmunity B lymphocytes Central tolerance Infant, newborn T lymphocytes T-cell receptor DNA 9007-49-2 Receptors, Antigen, T-Cell
Description
Résumé:Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: Dysregulated central tolerance predisposes to autoimmune diseases. Reduced thymic output as well as compromised central B cell tolerance checkpoints have been proposed in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of this study was to investigate neonatal levels of T-cell receptor excision circles (TRECs) and kappa-deleting element excision circles (KRECs), as markers of T- and B-cell output at birth, in patients with early onset JIA
METHODS: TRECs and KRECs were quantitated by multiplex qPCR from dried blood spots (DBS), collected 2-5 days after birth, in 156 children with early onset JIA and in 312 matched controls
RESULTS: When analysed from neonatal dried blood spots, the median TREC level was 78 (IQR 55-113) in JIA cases and 88 (IQR 57-117) copies/well in controls. The median KREC level was 51 (IQR 35-69) and 53 (IQR 35-74) copies/well, in JIA cases and controls, respectively. Stratification by sex and age at disease onset did not reveal any difference in the levels of TRECs and KRECs
CONCLUSION: T- and B-cell output at birth, as measured by TREC and KREC levels in neonatal dried blood spots, does not differ in children with early onset JIA compared to controls
Description:Date Completed 04.04.2023
Date Revised 11.04.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109277