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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202211632
|2 doi
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|a pubmed24n1179.xml
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|a (DE-627)NLM353740802
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|a (NLM)36868183
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Lee, Ka-Wai
|e verfasserin
|4 aut
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|a Anti-Quenching NIR-II J-Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 19.05.2023
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|a Date Revised 19.05.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used to construct long-wavelength NIR-II emitters as their optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, their wide applications in the NIR-II fluorescence imaging are impeded by the limited varieties of J-type backbone and serious fluorescence quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) with anti-quenching effect is reported for highly efficient NIR-II bioimaging and phototheranostics. The BT fluorophores are manipulated to have Stokes shift over 400 nm and aggregation-induced emission (AIE) property for conquering the self-quenching issue of the J-type fluorophores. Upon forming BT6 assemblies in an aqueous environment, the absorption over 800 nm and NIR-II emission over 1000 nm are boosted for more than 41 and 26 folds, respectively. In vivo visualization of the whole-body blood vessel and imaging-guided phototherapy results verify that BT6 NPs are excellent agent for NIR-II fluorescence imaging and cancer phototheranostics. This work develops a strategy to construct bright NIR-II J-aggregates with precisely manipulated anti-quenching properties for highly efficient biomedical applications
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|a Journal Article
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|a J-aggregates
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|a NIR-II fluorescence imaging
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|a aggregation-induced emission
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|a large Stokes shift
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|a molecular fluorophores
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|a phototheranostics
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|a Fluorescent Dyes
|2 NLM
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1 |
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|a Gao, Yijian
|e verfasserin
|4 aut
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1 |
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|a Wei, Wei-Chih
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tan, Ji-Hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wan, Yingpeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feng, Zhe
|e verfasserin
|4 aut
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1 |
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|a Zhang, Yuhuang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Ying
|e verfasserin
|4 aut
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1 |
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|a Zheng, Xiuli
|e verfasserin
|4 aut
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1 |
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|a Cao, Chen
|e verfasserin
|4 aut
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1 |
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|a Chen, Huan
|e verfasserin
|4 aut
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|a Wang, Pengfei
|e verfasserin
|4 aut
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|a Li, Shengliang
|e verfasserin
|4 aut
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| 700 |
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|a Wong, Ken-Tsung
|e verfasserin
|4 aut
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| 700 |
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|a Lee, Chun-Sing
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 20 vom: 15. Mai, Seite e2211632
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:35
|g year:2023
|g number:20
|g day:15
|g month:05
|g pages:e2211632
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|u http://dx.doi.org/10.1002/adma.202211632
|3 Volltext
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|d 35
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