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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202209789
|2 doi
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|a pubmed25n1178.xml
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|a eng
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| 100 |
1 |
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|a Zhang, Dongsheng
|e verfasserin
|4 aut
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| 245 |
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|a Ultra-Small Nano-Assemblies as Tumor-Targeted and Renal Clearable Theranostic Agent for Photodynamic Therapy
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 12.05.2023
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|a Date Revised 12.05.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a It is a challenge to design photosensitizers to balance between the tumor-targeting enrichment for precise treatment and efficient clearance within a reasonable timescale for reducing side effects. Herein, an ultra-small nano-photosensitizer 1a with excellent tumor-specific accumulation and renal clearance is reported. It is formed from the self-assembly of compound 1 bearing three triethylene glycol (TEG) arms and two pyridinium groups in water. The positively charged surface with neutral TEG coating enables 1a to efficiently target the tumor, with the signal-to-background ratio reaching as high as 11.5 after tail intravenous injection. The ultra-small size of 1a with an average diameter of 5.6 nm allows its fast clearance through kidney. Self-assembly also endows 1a with an 18.2-fold enhancement of reactive oxygygen species generation rate compared to compound 1 in organic solution. Nano-PS 1a manifests an excellent photodynamic therapy efficacy on tumor-bearing mouse models. This work provides a promising design strategy of photosensitizers with renal clearable and tumor-targeting ability
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|a Journal Article
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|a photodynamic therapy
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|a renal clearable
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|a self-assembly
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|a tumor targeting
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|a Photosensitizing Agents
|2 NLM
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| 650 |
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|a triethylene glycol
|2 NLM
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| 650 |
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|a 3P5SU53360
|2 NLM
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| 700 |
1 |
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|a Teng, Kun-Xu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Luyang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Niu, Li-Ya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Qing-Zheng
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 19 vom: 02. Mai, Seite e2209789
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
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|g volume:35
|g year:2023
|g number:19
|g day:02
|g month:05
|g pages:e2209789
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202209789
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