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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1111/vcp.13223
|2 doi
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|a pubmed25n1178.xml
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|a (DE-627)NLM353655805
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|a (NLM)36859602
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Tümer, Kenan C
|e verfasserin
|4 aut
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|a Evaluation of Freestyle Optium Neo H and TaiDoc-TD4235 point-of-care meters for measuring blood β-hydroxybutyrate concentration in sheep
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 06.06.2023
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|a Date Revised 06.06.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 American Society for Veterinary Clinical Pathology.
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|a BACKGROUND: Accurate and rapid measurement of blood β-hydroxybutyrate (β-OHB) concentrations is critical to identify hyperketonemia in sheep
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|a OBJECTIVE: The objective of this study was to test the performance of Freestyle Optium Neo H and TaiDoc-TD4235 point-of-care (POC) devices for measuring blood β-OHB concentrations in sheep
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|a METHODS: Venous blood samples from 105 sheep were evaluated with Freestyle Optium Neo H and TaiDoc-TD4235 meters. A reference approach was the laboratory measurement of serum BHB concentrations using the Randox D-3 Hydroxybutyrate reagent kit. Data were analyzed using Passing- Bablok regression and Bland-Altman analysis. The diagnostic accuracy was assessed using serum β-OHB concentration at a cut-off value of 0.8 mmol/L
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|a RESULTS: Passing-Bablok regression analysis revealed an intercept of 0.066 (CI95 : 0.018-0.125) and slope of 1.242 (CI95 : 1.136-1.342) for Freestyle Optium Neo H. Intercept and slope values for the TaiDoc-TD4235 meter were 0.625 (CI95 : 0.539-0.724) and 1.265 (CI95 : 1.044-1.497), respectively. The Bland-Altman plot revealed a bias of 0.224 mmol/L and 0.737 mmol/L for Freestyle Optium Neo H and TaiDoc-TD4235 meters, respectively, compared with the reference method. Observed Total Error (TEobs ) was 56.7% for the Freestyle Optium Neo H and 168.7% for the Taidoc-TD4235. The sensitivity and specificity for the Freestyle Optium Neo H were 100% and 80.9%, respectively, at the threshold of 0.8 mmol/L. The Taidoc-TD4235 demonstrated a sensitivity of 93.3% and specificity of 8.9% at the threshold of 0.8 mmol/L
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|a CONCLUSIONS: Because of the large TEobs , the Freestyle Optium Neo H and TaiDoc-TD4235 meters should not be used to quantify blood β-OHB concentrations in sheep
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|a Journal Article
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|a bias
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|a ewe
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|a point-of-care device
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|a pregnancy toxemia
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|a sensitivity
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|a specificity
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|a 3-Hydroxybutyric Acid
|2 NLM
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|a TZP1275679
|2 NLM
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| 650 |
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|a Blood Glucose
|2 NLM
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1 |
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|a Kılınç, Mehmet A
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 52(2023), 2 vom: 01. Juni, Seite 288-294
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnas
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| 773 |
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|g volume:52
|g year:2023
|g number:2
|g day:01
|g month:06
|g pages:288-294
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|u http://dx.doi.org/10.1111/vcp.13223
|3 Volltext
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