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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1111/jfd.13775
|2 doi
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|a pubmed24n1178.xml
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|a (DE-627)NLM353545635
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|a (NLM)36848441
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Turner, Jessica Kaye
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Tilapia lake virus (TiLV) causes severe anaemia and systemic disease in tilapia
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| 264 |
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|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 08.05.2023
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|a Date Revised 08.05.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 John Wiley & Sons Ltd.
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|a Tilapia lake virus disease (TiLVD) is an emerging disease in tilapia that is associated with mass mortality affecting global tilapia aquaculture. In this study, red hybrid tilapias (Oreochromis spp.) were experimentally infected by intracoelomic injection with Tilapia lake virus (TiLV) to gain a better understanding of the clinicopathological changes during infection. Pale bodies and gill were observed in infected fish after 7 days of post-challenge (dpc) associated with severe anaemia. Further haematological analysis in TiLV-infected fish revealed decreased levels of haemoglobin and haematocrit at 3 dpc. Common pathological findings included pale and friable liver, pale intestine with catarrhal content, and dark and shrunken spleen in TiLV-infected fish at 7 dpc and 14 dpc. Histologically, reduced numbers of red blood cells and accumulation of melano-macrophage centre in the spleen were found in infected fish at 3 dpc, and severe lesions were more commonly observed at 7 and 14 dpc. Lymphocyte infiltration, syncytial cell formation and multifocal necrotic hepatitis were the prominent pathological findings in the liver of infected fish. The severity of pathological changes was associated with TiLV-infection with higher viral loads and with the expression pattern of pro-inflammatory cytokines and antiviral genes, including interferon regulatory factor 1 (irf1), interleukin (il-8), radical s-adenosyl methionine domain containing 2 (rsad2) and mx. Our study provides a comprehensive analysis of the haematological profile and pathological changes in tilapia during TiLV infection. Overall, lesions present in various organs, together with alteration of host immune response in TiLV-infected fish, indicate the systemic infection of this virus. The knowledge gained from this study improves our understanding of how TiLV causes pathological and haematological changes in tilapia
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Tilapia lake virus
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| 650 |
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4 |
|a anaemia
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| 650 |
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4 |
|a haematology
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| 650 |
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4 |
|a pathological changes
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| 650 |
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4 |
|a red hybrid tilapia
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| 700 |
1 |
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|a Sakulpolwat, Sasakorn
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sukdanon, Suchanuch
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lertwanakarn, Tuchakorn
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Waiyamitra, Pitchaporn
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Piewbang, Chutchai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pierezan, Felipe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Techangamsuwan, Somporn
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Soto, Esteban
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Surachetpong, Win
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 46(2023), 6 vom: 19. Juni, Seite 643-651
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnns
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| 773 |
1 |
8 |
|g volume:46
|g year:2023
|g number:6
|g day:19
|g month:06
|g pages:643-651
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| 856 |
4 |
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|u http://dx.doi.org/10.1111/jfd.13775
|3 Volltext
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