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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1111/nph.18839
|2 doi
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|a pubmed24n1178.xml
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|a (DE-627)NLM353493821
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|a (NLM)36843261
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Zhou, Qingqian
|e verfasserin
|4 aut
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| 245 |
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|a Maize tubulin folding cofactor B is required for cell division and cell growth through modulating microtubule homeostasis
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 03.08.2023
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|a Date Revised 03.08.2023
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|a published: Print-Electronic
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|a CommentIn: New Phytol. 2023 Sep;239(5):1537-1538. - PMID 37391889
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|a Citation Status MEDLINE
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|a © 2023 The Authors. New Phytologist © 2023 New Phytologist Foundation.
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|a Tubulin folding cofactors (TFCs) are required for tubulin folding, α/β tubulin heterodimer formation, and microtubule (MT) dynamics in yeast and mammals. However, the functions of their plant counterparts remain to be characterized. We identified a natural maize crumpled kernel mutant, crk2, which exhibits reductions in endosperm cell number and size, as well as embryo/seedling lethality. Map-based cloning and functional complementation confirmed that ZmTFCB is causal for the mutation. ZmTFCB is targeted mainly to the cytosol. It facilitates α-tubulin folding and heterodimer formation through sequential interactions with the cytosolic chaperonin-containing TCP-1 ε subunit ZmCCT5 and ZmTFCE, thus affecting the organization of both the spindle and phragmoplast MT array and the cortical MT polymerization and array formation, which consequently mediated cell division and cell growth. We detected a physical association between ZmTFCB and the maize MT plus-end binding protein END-BINDING1 (ZmEB1), indicating that ZmTFCB1 may modulate MT dynamics by sequestering ZmEB1. Our data demonstrate that ZmTFCB is required for cell division and cell growth through modulating MT homeostasis, an evolutionarily conserved machinery with some species-specific divergence
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a cell division and growth
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| 650 |
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|a kernel development
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|a maize
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|a microtubule homeostasis
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|a tubulin folding cofactor B
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|a Tubulin
|2 NLM
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| 650 |
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|a Microtubule-Associated Proteins
|2 NLM
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| 700 |
1 |
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|a Fu, Zhiyuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Mengyuan
|e verfasserin
|4 aut
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| 700 |
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|a Shen, Qingwen
|e verfasserin
|4 aut
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| 700 |
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|a Sun, Canran
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feng, Yijian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Yang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Jianjun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qin, Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mao, Tonglin
|e verfasserin
|4 aut
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| 700 |
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|a Hearne, Sarah Jane
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Guifeng
|e verfasserin
|4 aut
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| 700 |
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|a Tang, Jihua
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 239(2023), 5 vom: 15. Sept., Seite 1707-1722
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:239
|g year:2023
|g number:5
|g day:15
|g month:09
|g pages:1707-1722
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|u http://dx.doi.org/10.1111/nph.18839
|3 Volltext
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