Multienzyme-Like Nanozymes Regulation, Rational Design, and Application

Multienzyme-Like Nanozymes : Regulation, Rational Design, and Application

© 2023 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 10 vom: 07. März, Seite e2211210
1. Verfasser: Sheng, Jingyi (VerfasserIn)
Weitere Verfasser: Wu, Yuehuang, Ding, He, Feng, Kaizheng, Shen, Yan, Zhang, Yu, Gu, Ning
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Review multienzyme-like nanozymes rational design regulation Hydrolases EC 3.-
Beschreibung
Zusammenfassung:© 2023 Wiley-VCH GmbH.
Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years and hold huge potential to be applied in diverse fields, especially for biosensing and therapeutics. Compared to single enzyme-like nanozymes, multienzymic nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, and environmentally responsive selectivity. Nevertheless, along with these merits, the catalytic mechanism and rational design of multienzymic nanozymes are more complicated and elusive as compared to single-enzymic nanozymes. In this review, the multienzymic nanozymes classification scheme based on the numbers/types of activities, the internal and external factors regulating the multienzymatic activities, the rational design based on chemical, biomimetic, and computer-aided strategies, and recent progress in applications attributed to the advantages of multicatalytic activities are systematically discussed. Finally, current challenges and future perspectives regarding the development and application of multienzymatic nanozymes are suggested. This review aims to deepen the understanding and inspire the research in multienzymic nanozymes to a greater extent
Beschreibung:Date Completed 08.03.2024
Date Revised 08.03.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202211210