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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202212300
|2 doi
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|a pubmed25n1176.xml
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|a eng
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|a Xiong, Yuan
|e verfasserin
|4 aut
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|a A Whole-Course-Repair System Based on Neurogenesis-Angiogenesis Crosstalk and Macrophage Reprogramming Promotes Diabetic Wound Healing
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|c 2023
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 12.05.2023
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|a Date Revised 12.05.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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|a Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis and angiogenesis have appeared to be a promising direction. However, the current treatments have failed to coordinate neurogenesis and angiogenesis simultaneously, leading to an increased disability rate caused by DWs. Herein, a whole-course-repair system is introduced by a hydrogel to concurrently achieve a mutually supportive cycle of neurogenesis-angiogenesis under a favorable immune-microenvironment. This hydrogel can first be one-step packaged in a syringe for later in situ local injections to cover wounds long-termly for accelerated wound healing via the synergistic effect of magnesium ions (Mg2+ ) and engineered small extracellular vesicles (sEVs). The self-healing and bio-adhesive properties of the hydrogel make it an ideal physical barrier for DWs. At the inflammation stage, the formulation can recruit bone marrow-derived mesenchymal stem cells to the wound sites and stimulate them toward neurogenic differentiation, while providing a favorable immune microenvironment via macrophage reprogramming. At the proliferation stage of wound repair, robust angiogenesis occurs by the synergistic effect of the newly differentiated neural cells and the released Mg2+ , allowing a regenerative neurogenesis-angiogenesis cycle to take place at the wound site. This whole-course-repair system provides a novel platform for combined DW therapy
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|a Journal Article
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|a angiogenesis
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|a diabetic wounds
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|a hydrogels
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|a macrophages
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|a neurogenesis
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|a Hydrogels
|2 NLM
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|a Lin, Ze
|e verfasserin
|4 aut
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|a Bu, Pengzhen
|e verfasserin
|4 aut
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|a Yu, Tao
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|a Endo, Yori
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|a Zhou, Wu
|e verfasserin
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|a Sun, Yun
|e verfasserin
|4 aut
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|a Cao, Faqi
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|a Dai, Guandong
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|a Hu, Yiqiang
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|4 aut
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|a Lu, Li
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|4 aut
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|a Chen, Lang
|e verfasserin
|4 aut
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|a Cheng, Peng
|e verfasserin
|4 aut
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|a Zha, Kangkang
|e verfasserin
|4 aut
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|a Shahbazi, Mohammad-Ali
|e verfasserin
|4 aut
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|a Feng, Qian
|e verfasserin
|4 aut
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|a Mi, Bobin
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|a Liu, Guohui
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 19 vom: 30. Mai, Seite e2212300
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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|g volume:35
|g year:2023
|g number:19
|g day:30
|g month:05
|g pages:e2212300
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|u http://dx.doi.org/10.1002/adma.202212300
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