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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202208820
|2 doi
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|a pubmed24n1177.xml
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|a (NLM)36810905
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Li, Xianlei
|e verfasserin
|4 aut
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|a Fluorescence-Amplified Origami Microneedle Device for Quantitatively Monitoring Blood Glucose
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 21.07.2023
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|a Date Revised 21.07.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Exploration of clinically acceptable blood glucose monitors has been engaging in the past decades, yet the ability to quantitatively detect blood glucose in a painless, accurate, and highly sensitive manner remains limited. Herein, a fluorescence-amplified origami microneedle (FAOM) device is described that integrates tubular DNA-origami nanostructures and glucose oxidase molecules into its inner network to quantitatively monitor blood glucose. The skin-attached FAOM device can collect glucose molecules in situ and transfer the input into a proton signal after the oxidase's catalysis. The proton-driven mechanical reconfiguration of DNA-origami tubes separates fluorescent molecules and their quenchers, eventually amplifying the glucose-correlated fluorescence signal. The function equation established on clinical examinees suggests that FAOM can report blood glucose in a highly sensitive and quantitative manner. In clinical blind tests, the FAOM achieves well-matched accuracy (98.70 ± 4.77%) compared with a commercial blood biochemical analyzer, fully meeting the requirements of accurate blood glucose monitoring. The FAOM device can be inserted into skin tissue in a trivially painful manner and with minimal leakage of DNA origami, substantially improving the tolerance and compliance of the blood glucose test
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|a Journal Article
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|a DNA origami
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|a blood glucose
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|a fluorescence quantification
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|a microneedle patches
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|a proton-driven
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|a Blood Glucose
|2 NLM
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|a Protons
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|a DNA
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|a 9007-49-2
|2 NLM
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|a Glucose
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|a IY9XDZ35W2
|2 NLM
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| 700 |
1 |
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|a Xu, Xuehui
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Kewei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Yuqiu
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Yangyuchen
|e verfasserin
|4 aut
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|a Si, Qingrui
|e verfasserin
|4 aut
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| 700 |
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|a Pan, Zi'an
|e verfasserin
|4 aut
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|a Jia, Fan
|e verfasserin
|4 aut
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|a Cui, Xinyue
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Xuan
|e verfasserin
|4 aut
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|a Deng, Xiongwei
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, Yi
|e verfasserin
|4 aut
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| 700 |
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|a Shu, Dan
|e verfasserin
|4 aut
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| 700 |
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|a Jiang, Qiao
|e verfasserin
|4 aut
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| 700 |
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|a Ding, Baoquan
|e verfasserin
|4 aut
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| 700 |
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|a Wu, Yan
|e verfasserin
|4 aut
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| 700 |
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|a Liu, Ran
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 29 vom: 21. Juli, Seite e2208820
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|7 nnns
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| 773 |
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|g volume:35
|g year:2023
|g number:29
|g day:21
|g month:07
|g pages:e2208820
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|u http://dx.doi.org/10.1002/adma.202208820
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