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20231226055324.0 |
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231226s2023 xx |||||o 00| ||eng c |
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7 |
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|a 10.1002/adma.202211509
|2 doi
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|a pubmed24n1177.xml
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|a (DE-627)NLM353137464
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|a (NLM)36807373
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Tang, Xiaofan
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Magnetic-Acoustic Sequentially Actuated CAR T Cell Microrobots for Precision Navigation and In Situ Antitumor Immunoactivation
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 12.05.2023
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|a Date Revised 12.05.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Despite its clinical success, chimeric antigen receptor T (CAR T)-cell immunotherapy remains limited in solid tumors, owing to the harsh physical barriers and immunosuppressive microenvironment. Here a CAR-T-cell-based live microrobot (M-CAR T) is created by decorating CAR T with immunomagnetic beads using click conjugation. M-CAR Ts are capable of magnetic-acoustic actuation for precision targeting and in situ activation of antitumor immune responses. Sequential actuation endows M-CAR Ts with magnetically actuated anti-flow and obstacle avoidance as well as tissue penetration driven by acoustic propulsion, enabling efficient migration and accumulation in artificial tumor models. In vivo, sequentially actuated M-CAR Ts achieves long-distance targeting and accumulate at the peritumoural area under programmable magnetic guidance, and subsequently acoustic tweezers actuate M-CAR Ts to migrate into deep tumor tissues, resulting in a 6.6-fold increase in accumulated exogenous CD8+ CAR T cells compared with that without actuation. Anti-CD3/CD28 immunomagnetic beads stimulate infiltrated CAR T proliferation and activation in situ, significantly enhancing their antitumor efficacy. Thus, this sequential-actuation-guided cell microrobot combines the merits of autonomous targeting and penetration of intelligent robots with in situ T-cell immunoactivation, and holds considerable promise for precision navigation and cancer immunotherapies
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4 |
|a Journal Article
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|a CAR T cell microrobots
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4 |
|a active targeting
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|a in situ immunoactivation
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| 650 |
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|a magnetic-acoustic sequential actuation
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| 650 |
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|a tumor immunotherapy
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| 650 |
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|a Receptors, Chimeric Antigen
|2 NLM
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| 700 |
1 |
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|a Yang, Ye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Mingbin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yin, Ting
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Guojun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lai, Zhengyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Baozhen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Ze
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Tiantian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Teng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pan, Hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cai, Lintao
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 18 vom: 18. Mai, Seite e2211509
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:35
|g year:2023
|g number:18
|g day:18
|g month:05
|g pages:e2211509
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202211509
|3 Volltext
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