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20231226055315.0 |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109270
|2 doi
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|a pubmed24n1177.xml
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|a (DE-627)NLM353130834
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|a (NLM)36806704
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|a (PII)S1521-6616(23)00049-9
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Kaneko, Shuya
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The dynamics of laboratory markers reflecting cytokine overproduction in macrophage activation syndrome complicated with systemic juvenile idiopathic arthritis
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|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.03.2023
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|a Date Revised 18.03.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 Elsevier Inc. All rights reserved.
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|a OBJECTIVES: To validate the correlation between laboratory markers reflecting disease activity of macrophage activation syndrome (MAS) and serum cytokine levels and identify the valuable laboratory markers that change over time for a prompt MAS diagnosis
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|a METHODS: Serum cytokine levels were determined by enzyme-linked immunosorbent assay and compared with laboratory markers reflecting MAS disease activity.The changes in values were evaluated from the acute phase of systemic juvenile idiopathic arthritis (s-JIA) to MAS diagnosis
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| 520 |
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|a RESULTS: CXCL9 was significantly correlated with aspartate aminotransferase (AST), lactate dehydrogenase (LDH), D dimer, and urine β2 microglobulin levels. sTNF-RII was significantly correlated with platelet counts, AST, LDH, D dimer, and ferritin levels. Significant changes in platelet count, LDH, and D dimer levels were observed. Decreased platelet counts were the most valuable indicator for MAS diagnosis
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|a CONCLUSION: Monitoring the laboratory markers that change over time, particularly decreased platelet counts, was valuable for the prompt MAS diagnosis in s-JIA
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a CXCL9
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| 650 |
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|a Cytokine
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| 650 |
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|a Macrophage activation syndrome
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| 650 |
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|a Platelet
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| 650 |
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|a Systemic juvenile idiopathic arthritis
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a Biomarkers
|2 NLM
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| 650 |
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|a Fibrin Fibrinogen Degradation Products
|2 NLM
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| 700 |
1 |
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|a Shimizu, Masaki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Miyaoka, Futaba
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shimbo, Asami
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Irabu, Hitoshi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mizuta, Mao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nakagishi, Yasuo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Iwata, Naomi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fujimura, Junya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mori, Masaaki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Morio, Tomohiro
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 248(2023) vom: 17. März, Seite 109270
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:248
|g year:2023
|g day:17
|g month:03
|g pages:109270
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2023.109270
|3 Volltext
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