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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109266
|2 doi
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|a pubmed24n1176.xml
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|a (DE-627)NLM353029556
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|a (NLM)36796469
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|a (PII)S1521-6616(23)00045-1
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Jiang, Jing
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Single-cell profiling identifies T cell subsets associated with control of tuberculosis dissemination
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.03.2023
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|a Date Revised 18.03.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 Elsevier Inc. All rights reserved.
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|a To identify T cell subsets associated with control of tuberculosis, single-cell transcriptome and T cell receptor sequencing were performed on total T cells from patients with tuberculosis and healthy controls. Fourteen distinct subsets of T cells were identified by unbiased UMAP clustering. A GZMK-expressing CD8+ cytotoxic T cell cluster and a SOX4-expressing CD4+ central memory T cell cluster were depleted, while a MKI67-expressing proliferating CD3+ T cell cluster was expanded in patients with tuberculosis compared with healthy controls. The ratio of Granzyme K-expressing CD8+CD161-Ki-67- and CD8+Ki-67+ T cell subsets was significantly reduced and inversely correlated with the extent of TB lesions in patients with TB. In contrast, ratio of Granzyme B-expressing CD8+Ki-67+ and CD4+CD161+Ki-67- T cells and Granzyme A-expressing CD4+CD161+Ki-67- T cells were correlated with the extent of TB lesions. It is concluded that granzyme K-expressing CD8+ T cell subsets might contribute to protection against tuberculosis dissemination
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Cellular immunity
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|a Infection and immunity
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| 650 |
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|a Single-cell transcriptome
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|a T-lymphocytes
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| 650 |
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|a Tuberculosis
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| 650 |
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|a Granzymes
|2 NLM
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| 650 |
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|a EC 3.4.21.-
|2 NLM
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| 650 |
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|a Ki-67 Antigen
|2 NLM
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| 650 |
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|a SOX4 protein, human
|2 NLM
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| 650 |
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|a SOXC Transcription Factors
|2 NLM
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| 700 |
1 |
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|a Cao, Zhihong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xiao, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Su, Jinwen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Jinhe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liang, Jianqin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Bingfen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Yanhua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhai, Fei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Ruo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Xiaoxing
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 248(2023) vom: 10. März, Seite 109266
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:248
|g year:2023
|g day:10
|g month:03
|g pages:109266
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2023.109266
|3 Volltext
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|a SYSFLAG_A
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|a GBV_ILN_11
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|a GBV_ILN_24
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