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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202300086
|2 doi
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|a pubmed25n1176.xml
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Liu, Tao
|e verfasserin
|4 aut
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|a Tumor-Specific Photothermal-Therapy-Assisted Immunomodulation via Multiresponsive Adjuvant Nanoparticles
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|c 2023
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 12.05.2023
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|a Date Revised 12.05.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Multiresponsive adjuvant nanoparticles (RMmAGL) are fabricated to perform tumor-specific photothermal therapy while regulating the behavior of tumor-associated immune cells for primary tumor eradication and metastasis inhibition. Core-satellite-like RMmAGL have a core of mannose-functionalized mesoporous silica nanoparticles loaded with the TLR7 agonist imiquimod (R837MSN-mannose) connected via hydrazone bonds to satellites of glutamine (Glu)- and lysine (Lys)-comodified gold nanoparticles (AuNPs-Glu/Lys). During therapy, the acidic environment in tumor tissue cleaves the hydrazone bonds to release AuNPs-Glu/Lys, which further accumulate in tumor cells. After internalization, photothermal agents (aggregated AuNPs-Glu/Lys) are generated in situ through the intratumoral enzyme-catalyzed reaction between Glu and Lys, resulting in tumor-specific photothermal therapy. The detachment of AuNPs-Glu/Lys also triggers the release of R837, which matured dendritic cells (DCs) via a vaccine-like mechanism along with the tumor-associated antigens generated by photothermal therapy. These matured DCs further activates surrounding T cells for immunotherapy. Moreover, the resulting free MSN-mannose serves as an artificial glycocalyx to continuously induce the polarization of tumor-associated macrophages from an immunosuppressive phenotype to an inflammatory phenotype, thus further enhancing immunotherapy. Both in vivo and in vitro experiments demonstrate significant inhibition of malignant tumors after therapy
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|a Journal Article
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|a metastasis inhibition
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|a multi-responsive adjuvant nanoparticles
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|a photothermal-assisted immune cells modulation
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|a primary tumor extermination
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|a tumor-specific photothermal therapy
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|a Adjuvants, Immunologic
|2 NLM
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|a Gold
|2 NLM
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| 650 |
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|a 7440-57-5
|2 NLM
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| 650 |
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|a Mannose
|2 NLM
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| 650 |
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|a PHA4727WTP
|2 NLM
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| 650 |
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|a TLR7 protein, human
|2 NLM
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| 700 |
1 |
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|a Zhu, Man
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Xiaowei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Xiaoyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yuan, Pingyun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tian, Ran
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Zeren
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yanmin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 18 vom: 12. Mai, Seite e2300086
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
8 |
|g volume:35
|g year:2023
|g number:18
|g day:12
|g month:05
|g pages:e2300086
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|u http://dx.doi.org/10.1002/adma.202300086
|3 Volltext
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