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|a 10.1016/j.clim.2023.109251
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|a pubmed24n1541.xml
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|a eng
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| 100 |
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|a Galletti, Jeremias G
|e verfasserin
|4 aut
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| 245 |
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|a Ectopic lymphoid structures in the aged lacrimal glands
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 14.03.2023
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|a Date Revised 21.09.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
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|a Aging is a complex biological process in which many organs are pathologically affected. We previously reported that aged C57BL/6J had increased lacrimal gland (LG) lymphoid infiltrates that suggest ectopic lymphoid structures. However, these ectopic lymphoid structures have not been fully investigated. Using C57BL/6J mice of different ages, we analyzed the transcriptome of aged murine LGs and characterized the B and T cell populations. Age-related changes in the LG include increased differentially expressed genes associated with B and T cell activation, germinal center formation, and infiltration by marginal zone-like B cells. We also identified an age-related increase in B1+ cells and CD19+B220+ cells. B220+CD19+ cells were GL7+ (germinal center-like) and marginal zone-like and progressively increased with age. There was an upregulation of transcripts related to T follicular helper cells, and the number of these cells also increased as mice aged. Compared to a mouse model of Sjögren syndrome, aged LGs have similar transcriptome responses but also unique ones. And lastly, the ectopic lymphoid structures in aged LGs are not exclusive to a specific mouse background as aged diverse outbred mice also have immune infiltration. Altogether, this study identifies a profound change in the immune landscape of aged LGs where B cells become predominant. Further studies are necessary to investigate the specific function of these B cells during the aged LGs
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Aging
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|a B cells
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|a Dry eye
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| 650 |
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|a Ectopic lymphoid structures
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| 650 |
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4 |
|a Lacrimal gland
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| 650 |
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4 |
|a Tertiary lymphoid organs
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| 700 |
1 |
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|a Scholand, Kaitlin K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Trujillo-Vargas, Claudia M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Zhiyuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mauduit, Olivier
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Delcroix, Vanessa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Makarenkova, Helen P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a de Paiva, Cintia S
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 248(2023) vom: 16. März, Seite 109251
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|g year:2023
|g day:16
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|g pages:109251
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|u http://dx.doi.org/10.1016/j.clim.2023.109251
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