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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202210956
|2 doi
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|a pubmed25n1174.xml
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|a (DE-627)NLM352481366
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|a (NLM)36738115
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wang, Ying
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Breaking the Photostability and pH Limitation of Halo-Fluoresceins through Chitosan Conjugation
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 07.04.2023
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|a Date Revised 07.04.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Halo-fluoresceins are widely used in cell and tissue staining, intracellular sensing, and photodynamic therapy, but their notorious photo-instability and pH dependence restrict their applications, especially in long-term visible light exposure and acidic environments. To overcome these limitations, here a strategy is proposed of conjugating chitosan with the carboxyl group of halo-fluorescein (CS-halofluorescein). The cross-linked polymer chains and the hydrogen-bonding networks of chitosan help shielding out 1 O2 from direct attacking the encapsulated halo-fluoresceins, leading to a two orders of magnitude lower photobleaching rate. Meanwhile, the condensation of primary amines of chitosan with the carboxyl group on halo-fluorescein blocks the pH-dependent intramolecular spirocyclization, leading to pH-inert fluorescein derivatives. The greatly improved photostability and pH inertness of CS-halofluoresceins can be harvested for aerobic photoredox synthesis and photodynamic bacteria inactivation in extremely acidic media. Moreover, food additive nature of chitosan and erythrosine (TIF) and excellent film-forming property of chitosan allow coating-based light-assisted preservation of perishable fruits, leading to appreciably extended shelf life of fruits (e.g., perishable strawberry, rt: > 3 days; 4 °C: > 5 days)
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4 |
|a Journal Article
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|a chitosan
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4 |
|a halo-fluoresceins
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4 |
|a light-assisted fruits preservation
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| 650 |
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4 |
|a pH
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| 650 |
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4 |
|a photo-redox synthesis
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| 650 |
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4 |
|a photostability
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| 650 |
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7 |
|a Fluoresceins
|2 NLM
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| 650 |
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7 |
|a Chitosan
|2 NLM
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| 650 |
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7 |
|a 9012-76-4
|2 NLM
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| 650 |
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7 |
|a Fluorescein
|2 NLM
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| 650 |
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7 |
|a TPY09G7XIR
|2 NLM
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| 700 |
1 |
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|a Lang, Yunhe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Qin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Peng
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 14 vom: 07. Apr., Seite e2210956
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
8 |
|g volume:35
|g year:2023
|g number:14
|g day:07
|g month:04
|g pages:e2210956
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202210956
|3 Volltext
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