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|a 10.3760/cma.j.cn112140-20220711-00637
|2 doi
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|a pubmed25n1174.xml
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|a (DE-627)NLM352309636
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|a (NLM)36720600
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|a DE-627
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|c DE-627
|e rakwb
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|a chi
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| 100 |
1 |
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|a Cui, J Y
|e verfasserin
|4 aut
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| 245 |
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|a Short-term efficacy of dapagliflozin in children with hereditary proteinuric kidney disease
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|c 2023
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 02.02.2023
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|a Date Revised 02.02.2023
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|a published: Print
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|a Citation Status MEDLINE
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|a Objective: To explore the short-term efficacy and safety of dapagliflozin in children with hereditary proteinuric kidney disease. Methods: This was a prospective cohort study. From August 2020 to December 2021, 23 children with hereditary kidney disease from Children's Hospital of Fudan University were enrolled. Patients received dapagliflozin 5 mg/d (weight≤30 kg) or initial dose 5 mg/d for 1 week, then 10 mg/d (weight>30 kg) and the dose of angiotensin converting enzyme inhibitors was stable during treatment. Clinical data including demographic parameters, primary diagnosis, estimated glomerular filtration rate (eGFR), 24 h proteinuria and characteristics in the follow-up were collected. The primary outcome was the change in 24 h proteinuria at 12 (±2) weeks, secondary outcomes included changes of 24 h proteinuria at 24 (±2) weeks, eGFR at both 12 (±2) and 24 (±2) weeks. The data were analysed by using mixed linear model. Results: Totally 23 patients were enrolled, including 16 males and 7 females. The age was (10.8±2.9) years. The primary diseases were Alport syndrome (12 cases), Dent disease (5 cases), proteinuria (4 cases), and focal segmental glomerulosclerosis (2 cases) respectively. Primary outcome showed that 24 h proteinuria decreased from baseline at 12 (±2) weeks during treatment (1.75 (1.46, 2.20) vs. 1.84 (1.14, 2.54) g/m2, P<0.05). Secondary outcomes showed that there was no significant difference in 24 h urine protein at 24 (±2) weeks (P>0.05). eGFR decreased slightly at 12 (±2) weeks ((107±21) vs. (112±28) ml/(min·1.73m2), P<0.05), and there was no significant difference at 24 (±2) weeks (P>0.05). Serum albumin increased at 12 (±2) and 24 (±2) weeks following the treatment ((39±8) vs. (37±8) g/L, (38±7) vs. (37±8) g/L, both P<0.05). No hypoglycemia event was reported during the treatment. Conclusion: The dapagliflozin had therapeutic effects on decreasing proteinuria and increasing serum albumin in short-term treatment in children with hereditary proteinuric kidney disease, no hypoglycemia or serious adverse events were observed
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|a English Abstract
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|a Journal Article
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|a dapagliflozin
|2 NLM
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|a 1ULL0QJ8UC
|2 NLM
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|a Serum Albumin
|2 NLM
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|a Liu, J J
|e verfasserin
|4 aut
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| 700 |
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|a Fang, X Y
|e verfasserin
|4 aut
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| 700 |
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|a Chen, J
|e verfasserin
|4 aut
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1 |
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|a Zhai, Y H
|e verfasserin
|4 aut
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1 |
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|a Xu, H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Q
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 61(2023), 2 vom: 02. Feb., Seite 164-168
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnas
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| 773 |
1 |
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|g volume:61
|g year:2023
|g number:2
|g day:02
|g month:02
|g pages:164-168
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|u http://dx.doi.org/10.3760/cma.j.cn112140-20220711-00637
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