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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202208989
|2 doi
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|a pubmed24n1173.xml
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|a (DE-627)NLM352168188
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|a (NLM)36706357
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Im, Gwang-Bum
|e verfasserin
|4 aut
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| 245 |
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|a Ceria Nanoparticles as Copper Chaperones that Activate SOD1 for Synergistic Antioxidant Therapy to Treat Ischemic Vascular Diseases
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 21.04.2023
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|a Date Revised 21.04.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a All exogenous nanomaterials undergo rapid biotransformation once injected into the body and fall short of executing the intended purpose. Here, it is reported that copper-deposited ceria nanoparticles (CuCe NPs) exhibit enhanced antioxidant effects over pristine ceria nanoparticles, as the released copper buffers the depletion of glutathione while providing the bioavailable copper as a cofactor for the antioxidant enzyme, superoxide dismutase 1. The upregulated intracellular antioxidants along with the ceria nanoparticles synergistically scavenge reactive oxygen species and promote anti-inflammation and M2 polarization of macrophages by modulating signal transducer and activator of transcription 1 and 6 (STAT1 and STAT6). The therapeutic effect of CuCe NPs is demonstrated in ischemic vascular diseases (i.e., murine models of hindlimb ischemia and myocardial infarction) in which the copper-deposition affords increased perfusion and alleviation in tissue damage. The results provide rationale that metal oxide nanomaterials can be designed in a way to induce the upregulation of specific biological factors for optimal therapeutic performance
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|a Journal Article
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|a anti-inflammation
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|a antioxidants
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|a nanozymes
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|a oxidative stress
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|a superoxide dismutase 1
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|a Antioxidants
|2 NLM
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|a Copper
|2 NLM
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|a 789U1901C5
|2 NLM
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|a Superoxide Dismutase-1
|2 NLM
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| 650 |
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|a EC 1.15.1.1
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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|a SOD1 protein, human
|2 NLM
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1 |
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|a Kim, Young Geon
|e verfasserin
|4 aut
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1 |
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|a Yoo, Tae Yong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Yeong Hwan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Kang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hyun, Jiyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Soh, Min
|e verfasserin
|4 aut
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1 |
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|a Hyeon, Taeghwan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bhang, Suk Ho
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 16 vom: 13. Apr., Seite e2208989
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:35
|g year:2023
|g number:16
|g day:13
|g month:04
|g pages:e2208989
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202208989
|3 Volltext
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