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NLM351933069 |
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DE-627 |
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20240202231923.0 |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109239
|2 doi
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|a pubmed24n1278.xml
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|a (DE-627)NLM351933069
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|a (NLM)36682593
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|a (PII)S1521-6616(23)00018-9
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Alduraibi, Fatima K
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Interrelation of T cell cytokines and autoantibodies in systemic lupus erythematosus
|b A cross-sectional study
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1 |
|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 14.02.2023
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| 500 |
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|a Date Revised 02.02.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Published by Elsevier Inc.
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|a T-helper cytokines interferon gamma (IFNɣ), interleukin 17 (IL-17) and IL-10 impact systemic lupus erythematosus (SLE) directly and indirectly via modulation of autoAb production. We determined the separate and combined effects on clinical manifestations of SLE (N = 62). IFNɣ, IL-17 but not IL-10 were significantly elevated in patients with SLE. IFNɣ positively correlated with anti-DNA and anti-SSA. IL-17 positively correlated with anti-SSA and was significantly higher in patients with discoid rash and class V LN. IL-10 did not correlate with circulating autoantibodies but was significantly elevated in patients with LN. Patients with LN had elevated plasma levels of anti-DNA and anti-Sm/ribonuclear protein (RNP). Anti-Sm/RNP levels were decreased in patients with acute mucocutaneous manifestations, including photosensitivity and/or malar rash. The study provides critical insights into pathological mechanisms of LN, which could help guide future diagnoses and therapies
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| 650 |
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|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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4 |
|a Interferon gamma
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| 650 |
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4 |
|a Interleukin 10
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| 650 |
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4 |
|a Interleukin 17
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| 650 |
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4 |
|a Lupus nephritis
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| 650 |
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4 |
|a Systemic lupus erythematosus
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| 650 |
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7 |
|a Cytokines
|2 NLM
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| 650 |
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7 |
|a Interleukin-17
|2 NLM
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 650 |
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7 |
|a Antibodies, Antinuclear
|2 NLM
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| 700 |
1 |
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|a Sullivan, Kathryn A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chatham, W Winn
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hsu, Hui-Chen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mountz, John D
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 247(2023) vom: 01. Feb., Seite 109239
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:247
|g year:2023
|g day:01
|g month:02
|g pages:109239
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2023.109239
|3 Volltext
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|a GBV_ILN_24
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|a AR
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| 952 |
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|d 247
|j 2023
|b 01
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