Reshaping the Endogenous Electric Field to Boost Wound Repair via Electrogenerative Dressing

Reshaping the Endogenous Electric Field to Boost Wound Repair via Electrogenerative Dressing

© 2023 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 16 vom: 08. Apr., Seite e2208395
1. Verfasser: Luo, Ruizeng (VerfasserIn)
Weitere Verfasser: Liang, Yi, Yang, Jinrui, Feng, Hongqing, Chen, Ying, Jiang, Xupin, Zhang, Ze, Liu, Jie, Bai, Yuan, Xue, Jiangtao, Chao, Shengyu, Xi, Yi, Liu, Xiaoqiang, Wang, Engui, Luo, Dan, Li, Zhou, Zhang, Jiaping
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article electric field therapy epithelial regeneration negative-pressure wound therapy self-powered electrical simulation dressings triboelectric nanogenerators
LEADER 01000naa a22002652 4500
001 NLM351925805
003 DE-627
005 20231226052548.0
007 cr uuu---uuuuu
008 231226s2023 xx |||||o 00| ||eng c
024 7 |a 10.1002/adma.202208395  |2 doi 
028 5 2 |a pubmed24n1173.xml 
035 |a (DE-627)NLM351925805 
035 |a (NLM)36681867 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Luo, Ruizeng  |e verfasserin  |4 aut 
245 1 0 |a Reshaping the Endogenous Electric Field to Boost Wound Repair via Electrogenerative Dressing 
264 1 |c 2023 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 21.04.2023 
500 |a Date Revised 21.04.2023 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a © 2023 Wiley-VCH GmbH. 
520 |a The endogenous electric field (EF) generated by transepithelial potential difference plays a decisive role in wound reepithelialization. For patients with large or chronic wounds, negative-pressure wound therapy (NPWT) is the most effective clinical method in inflammation control by continuously removing the necrotic tissues or infected substances, thus creating a proproliferative microenvironment beneficial for wound reepithelialization. However, continuous negative-pressure drainage causes electrolyte loss and weakens the endogenous EF, which in turn hinders wound reepithelialization. Here, an electrogenerative dressing (EGD) is developed by integrating triboelectric nanogenerators with NPWT. By converting the negative-pressure-induced mechanical deformation into electricity, EGD produces a stable and high-safety EF that can trigger a robust epithelial electrotactic response and drive the macrophages toward a reparative M2 phenotype in vitro. Translational medicine studies confirm that EGD completely reshapes the wound EF weakened by NPWT, and promotes wound closure by facilitating an earlier transition of inflammation/proliferation and guiding epithelial migration and proliferation to accelerate reepithelialization. Long-term EGD therapy remarkably advances tissue remodeling with mature epithelium, orderly extracellular matrix, and less scar formation. Compared with the golden standard of NPWT, EGD orchestrates all the essential wound stages in a noninvasive manner, presenting an excellent prospect in clinical wound therapy 
650 4 |a Journal Article 
650 4 |a electric field therapy 
650 4 |a epithelial regeneration 
650 4 |a negative-pressure wound therapy 
650 4 |a self-powered electrical simulation dressings 
650 4 |a triboelectric nanogenerators 
700 1 |a Liang, Yi  |e verfasserin  |4 aut 
700 1 |a Yang, Jinrui  |e verfasserin  |4 aut 
700 1 |a Feng, Hongqing  |e verfasserin  |4 aut 
700 1 |a Chen, Ying  |e verfasserin  |4 aut 
700 1 |a Jiang, Xupin  |e verfasserin  |4 aut 
700 1 |a Zhang, Ze  |e verfasserin  |4 aut 
700 1 |a Liu, Jie  |e verfasserin  |4 aut 
700 1 |a Bai, Yuan  |e verfasserin  |4 aut 
700 1 |a Xue, Jiangtao  |e verfasserin  |4 aut 
700 1 |a Chao, Shengyu  |e verfasserin  |4 aut 
700 1 |a Xi, Yi  |e verfasserin  |4 aut 
700 1 |a Liu, Xiaoqiang  |e verfasserin  |4 aut 
700 1 |a Wang, Engui  |e verfasserin  |4 aut 
700 1 |a Luo, Dan  |e verfasserin  |4 aut 
700 1 |a Li, Zhou  |e verfasserin  |4 aut 
700 1 |a Zhang, Jiaping  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 35(2023), 16 vom: 08. Apr., Seite e2208395  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:35  |g year:2023  |g number:16  |g day:08  |g month:04  |g pages:e2208395 
856 4 0 |u http://dx.doi.org/10.1002/adma.202208395  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 35  |j 2023  |e 16  |b 08  |c 04  |h e2208395