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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202208250
|2 doi
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|a pubmed24n1172.xml
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|a (DE-627)NLM35191191X
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|a (NLM)36680474
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Kim, Jae-Myoung
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Plasmonic Dual-Gap Nanodumbbells for Label-Free On-Particle Raman DNA Assays
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.04.2023
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|a Date Revised 14.04.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Metal nanostructures with a tunable plasmonic gap are useful for photonics, surface-enhanced spectroscopy, biosensing, and bioimaging applications. The use of these structures as chemical and biological sensing/imaging probes typically requires an ultra-precise synthesis of the targeted nanostructure in a high yield, with Raman dye-labeling and complex assay components and procedures. Here, a plasmonic nanostructure with tunable dual nanogaps, Au dual-gap nanodumbbells (AuDGNs), is designed and synthesized via the anisotropic adsorption of polyethyleneimine on Au nanorods to facilitate tip-selective Au growths on nanorod tips for forming mushroom-shaped dumbbell-head structures at both tips and results in dual gaps (intra-head and inter-head gaps) within a single particle. AuDGNs are synthesized in a high yield (>90%) while controlling the inter-head gap size, and the average surface-enhanced Raman scattering (SERS) enhancement factor (EF) value is 7.5 × 108 with a very narrow EF distribution from 1.5 × 108 to 1.5 × 109 for >90% of analyzed particles. Importantly, AuDGNs enable label-free on-particle SERS detection assays through the diffusion of target molecules into the intraparticle gap for different DNA sequences with varying ATGC combinations in a highly specific and sensitive manner without a need for Raman dyes
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|a Journal Article
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|a anisotropic metal nanostructures
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|a label-free SERS detection
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|a plasmonic Au dual-gap nanodumbbells
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4 |
|a plasmonic nanogaps
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4 |
|a single-particle SERS assays
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4 |
|a surface-enhanced Raman scattering
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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|a DNA
|2 NLM
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|a 9007-49-2
|2 NLM
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| 700 |
1 |
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|a Kim, Jiyeon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Choi, Kyungin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nam, Jwa-Min
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 15 vom: 21. Apr., Seite e2208250
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:35
|g year:2023
|g number:15
|g day:21
|g month:04
|g pages:e2208250
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202208250
|3 Volltext
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|d 35
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