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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erad018
|2 doi
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|a pubmed24n1172.xml
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|a (DE-627)NLM351625933
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|a (NLM)36651789
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Ito, Takehiro
|e verfasserin
|4 aut
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|a Degradation of glutathione and glutathione conjugates in plants
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 08.06.2023
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|a Date Revised 13.06.2023
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a Glutathione (GSH) is a ubiquitous, abundant, and indispensable thiol for plants that participates in various biological processes, such as scavenging reactive oxygen species, redox signaling, storage and transport of sulfur, detoxification of harmful substances, and metabolism of several compounds. Therefore knowledge of GSH metabolism is essential for plant science. Nevertheless, GSH degradation has been insufficiently elucidated, and this has hampered our understanding of plant life. Over the last five decades, the γ-glutamyl cycle has been dominant in GSH studies, and the exoenzyme γ-glutamyl transpeptidase has been regarded as the major GSH degradation enzyme. However, recent studies have shown that GSH is degraded in cells by cytosolic enzymes such as γ-glutamyl cyclotransferase or γ-glutamyl peptidase. Meanwhile, a portion of GSH is degraded after conjugation with other molecules, which has also been found to be carried out by vacuolar γ-glutamyl transpeptidase, γ-glutamyl peptidase, or phytochelatin synthase. These findings highlight the need to re-assess previous assumptions concerning the γ-glutamyl cycle, and a novel overview of the plant GSH degradation pathway is essential. This review aims to build a foundation for future studies by summarizing current understanding of GSH/glutathione conjugate degradation
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|a Review
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Arabidopsis
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|a glucosinolate metabolism
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|a glutathione metabolism
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|a phytochelatin synthase
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|a redox regulation
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|a sulfur metabolism
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|a γ-glutamyl cycle
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|a γ-glutamyl cyclotransferase
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|a γ-glutamyl peptidase
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|a γ-glutamyl transpeptidase
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|a gamma-Glutamyltransferase
|2 NLM
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|a EC 2.3.2.2
|2 NLM
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|a Peptide Hydrolases
|2 NLM
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|a EC 3.4.-
|2 NLM
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|a Glutathione
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|a GAN16C9B8O
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|a Ohkama-Ohtsu, Naoko
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 74(2023), 11 vom: 06. Juni, Seite 3313-3327
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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|g volume:74
|g year:2023
|g number:11
|g day:06
|g month:06
|g pages:3313-3327
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|u http://dx.doi.org/10.1093/jxb/erad018
|3 Volltext
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