The transcription factor AtMYB12 is part of a feedback loop regulating cell division orientation in the root meristem vasculature

Bibliographische Detailangaben
Veröffentlicht in:	Journal of experimental botany. - 1985. - 74(2023), 6 vom: 28. März, Seite 1940-1956
1. Verfasser:	Wybouw, Brecht (VerfasserIn)
Weitere Verfasser:	Arents, Helena E, Yang, Baojun, Nolf, Jonah, Smet, Wouter, Vandorpe, Michael, Minne, Max, Luo, Xiaopeng, De Clercq, Inge, Van Damme, Daniël, Glanc, Matouš, De Rybel, Bert
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2023
Zugriff auf das übergeordnete Werk:	Journal of experimental botany
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Arabidopsis thaliana EMS screen cytokinin root development transcription factors vascular development Arabidopsis Proteins Transcription Factors mehr... Trans-Activators Cytokinins LHW protein, Arabidopsis

Beschreibung
Zusammenfassung:	© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com. Transcriptional networks are crucial to integrate various internal and external signals into optimal responses during plant growth and development. In Arabidopsis thaliana, primary root vasculature patterning and proliferation are controlled by a network centred around the basic Helix-Loop-Helix transcription factor complex, formed by TARGET OF MONOPTEROS 5 (TMO5) and LONESOME HIGHWAY (LHW), which control cell proliferation and division orientation by modulating the cytokinin response and other downstream factors. Despite recent progress, many aspects of the TMO5/LHW pathway are not fully understood. In particular, the upstream regulators of TMO5/LHW activity remain unknown. Here, using a forward genetics approach to identify new factors of the TMO5/LHW pathway, we discovered a novel function of the MYB-type transcription factor, MYB12. MYB12 physically interacts with TMO5 and dampens the TMO5/LHW-mediated induction of direct target gene expression, as well as the periclinal/radial cell divisions. The expression of MYB12 is activated by the cytokinin response, downstream of TMO5/LHW, resulting in a novel MYB12-mediated negative feedback loop that restricts TMO5/LHW activity, to ensure optimal cell proliferation rates during root vascular development
Beschreibung:	Date Completed 30.03.2023 Date Revised 03.10.2023 published: Print Citation Status MEDLINE
ISSN:	1460-2431
DOI:	10.1093/jxb/erad020