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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109234
|2 doi
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|a pubmed25n1171.xml
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|a (NLM)36649749
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|a (PII)S1521-6616(23)00013-X
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Xing, Yu-Jie
|e verfasserin
|4 aut
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| 245 |
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|a LncRNA HEM2ATM improves obesity-associated adipose tissues meta-inflammation and insulin resistance by interacting with heterogeneous nuclear ribonucleoprotein U
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.02.2023
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|a Date Revised 18.03.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023. Published by Elsevier Inc.
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|a Obesity is a complicated metabolic disease characterized by meta-inflammation in adipose tissues. In this study, we explored the roles of a new long non-coding RNA (lncRNA), HEM2ATM, which is highly expressed in adipose tissue M2 macrophages, in modulating obesity-associated meta-inflammation and insulin resistance. HEM2ATM expression decreased significantly in adipose tissue macrophages (ATMs) obtained from epididymal adipose tissues of high-fat diet (HFD)-induced obese mice. Overexpression of macrophage HEM2ATM improved meta-inflammation and insulin resistance in the adipose tissues of HFD-fed mice. Functionally, HEM2ATM negatively regulated the production of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in macrophages. Mechanistically, HEM2ATM bound to heterogeneous nuclear ribonucleoprotein U (hnRNP U), suppressed hnRNP U translocation from the nucleus to the cytoplasm, hindered the function of cytoplasmic hnRNP U on TNF-α and IL-6 mRNA stabilization, and decreased the secretion of TNF-α and IL-6. Collectively, HEM2ATM is a novel suppressor of obesity-associated meta-inflammation and insulin resistance
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Insulin resistance
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|a Long non-coding RNA
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|a Macrophages
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|a Obesity
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|a Heterogeneous-Nuclear Ribonucleoprotein U
|2 NLM
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| 650 |
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|a RNA, Long Noncoding
|2 NLM
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| 650 |
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|a Interleukin-6
|2 NLM
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| 650 |
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|a Tumor Necrosis Factor-alpha
|2 NLM
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| 700 |
1 |
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|a Zhang, Teng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wan, Shu-Jun
|e verfasserin
|4 aut
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| 700 |
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|a Cheng, Yi
|e verfasserin
|4 aut
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| 700 |
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|a Zhou, Si-Min
|e verfasserin
|4 aut
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| 700 |
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|a Sun, Yue
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Hao-Ran
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yao, Xin-Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hua, Qiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meng, Xiang-Jian
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lv, Kun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Chunxiao
|e verfasserin
|4 aut
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| 700 |
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|a Kong, Xiang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 247(2023) vom: 28. Feb., Seite 109234
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
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|g volume:247
|g year:2023
|g day:28
|g month:02
|g pages:109234
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|u http://dx.doi.org/10.1016/j.clim.2023.109234
|3 Volltext
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